Methylation and MicroRNA Profiling to Understand Racial Disparities of Prostate Cancer.
Methylation and MicroRNA Profiling to Understand Racial Disparities of Prostate Cancer.
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甲基化和 MicroRNA 分析可了解前列腺癌的种族差异。
DOI：
10.1007/978-1-4939-8751-1_15
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Verma,Mukesh
中科院分区：
文献类型：
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作者：
Banerjee,HirendraNath;Kahan,William;Kumar,Vineet;Verma,Mukesh
前列腺癌在美国和世界各地的发病率和死亡率都很高，是一种严重的疾病。前列腺特异性抗原(PSA)已被用于前列腺癌的诊断和治疗的后续治疗，但仍存在一些挑战。表观遗传生物标记物，特别是甲基化和microRNA(MiR)生物标记物为前列腺癌的诊断、预后和复发提供了机会。差异全球甲基化已显示出一些有希望的结果。在这一章中，重点是那些可以在前瞻性研究和临床中进行非侵入性检测的生物标志物。本章提供了该领域的挑战，特别是潜在生物标志物的验证，以及它们的潜在解决方案。
Prostate cancer is a serious disease in terms of its high incidence and mortality rate in the USA and around the world. The prostate specific antigen (PSA) has been used for prostate cancer diagnosis and follow-up of treatment but a number of challenges remain. Epigenetic biomarkers, especially methylation and microRNA (miR) biomarkers provide an opportunity for diagnosis, prognosis, and recurrence of prostate cancer. Differential global methylation has shown some promising results. In this chapter, the emphasis is given on those biomarkers which can be assayed noninvasively in a prospective study and in a clinic. Challenges in the field, especially the validation of potential biomarkers, and their potential solutions are provided in this chapter.