Hybrid Modeling and Simulation of Genetic Regulatory Networks: A Qualitative Approach
Hybrid Modeling and Simulation of Genetic Regulatory Networks: A Qualitative Approach
复制标题
遗传调控网络的混合建模和模拟：定性方法
DOI：
10.1007/3-540-36580-x_21
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
J. Geiselmann
中科院分区：
文献类型：
--
作者：
H. Jong;J. Gouzé;Céline Hernandez;M. Page;S. Tewfik;J. Geiselmann
遗传调控网络的研究已经收到了一个主要的推动力，从最近的发展，实验技术允许测量模式的基因表达在一个大规模的并行方式。这一实验进展要求开发适当的计算机工具，用于基因调控过程的建模和模拟。我们提出了一种遗传调控网络的混合建模和仿真方法，基于一类分段线性（PL）微分方程，已在数学生物学中得到充分研究。该方法的显着特点是，它使监管系统的行为的定性预测，它处理的微分方程的右手边的不连续性。该模拟方法已在计算机工具遗传网络分析仪（GNA）中用Java实现。该方法和工具已被用来分析几个网络的生物利益，包括网络的基础上启动芽孢杆菌枯草芽孢杆菌。
The study of genetic regulatory networks has received a major impetus from the recent development of experimental techniques allowing the measurement of patterns of gene expression in a massively parallel way. This experimental progress calls for the development of appropriate computer tools for the modeling and simulation of gene regulation processes. We present a method for the hybrid modeling and simulation of genetic regulatory networks, based on a class of piecewiselinear (PL) differential equations that has been well-studied in mathematical biology. Distinguishing characteristics of the method are that it makes qualitative predictions of the behavior of regulatory systems and that it deals with discontinuities in the right-hand side of the differential equations. The simulation method has been implemented in Java in the computer tool Genetic Network Analyzer (GNA). The method and the tool have been used to analyze several networks of biological interest, including the network underlying the initiation of sporulation in Bacillus subtilis.
DOI：
10.1073/pnas.140209597
发表时间：
2000-07-05
影响因子：
11.1
作者：
Fawcett, P;Eichenberger, P;Youngman, P
通讯作者：
Youngman, P