Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults
Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults
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DOI：
10.3945/ajcn.2009.28380
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发表时间：
2009-11-01
影响因子：
7.1
通讯作者：
Klempel, Monica C.
中科院分区：
文献类型：
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作者：
Varady, Krista A.;Bhutani, Surabhi;Klempel, Monica C.
背景资料：改良隔日禁食的能力（ADF;即在禁食当天消耗25%的能量需求，第二天随意进食）促进肥胖个体减肥和降低血管疾病风险的作用尚不清楚。目的：本研究检查了ADF在控制条件下与自我实施条件下给药对体重和冠状动脉疾病（CAD）的影响研究设计：16名肥胖受试者（12名女性，4名男性）完成了为期10周的试验，该试验包括3个阶段：1）2周的对照阶段，2）4周的体重减轻/ADF控制食物摄入阶段，和3）4周的体重减轻/ADF自选食物摄入阶段。在整个控制食物摄入阶段（依从天数：86%）和自选食物摄入阶段（依从天数：89%），饮食依从性保持较高水平。在控制食物摄入（0.67 +/- 0.1 kg/周）和自选食物摄入阶段（0.68 +/- 0.1 kg/周），体重减轻率保持不变。喂食8周后，体重下降（P < 0.001）5.6 +/- 1.0 kg（5.8 +/- 1.1%）。体脂百分比从45 +/- 2%降至42 +/-2%（P < 0.01）。ADF治疗8周后，总胆固醇、LDL胆固醇和三酰甘油浓度分别降低了21 +/-4%、25 +/-10%和32 +/-6%（P < 0.01），而HDL胆固醇保持不变。收缩压从124 +/- 5降至116 +/- 3 mm Hg（P < 0.05）。结论：这些发现表明ADF是一种可行的饮食选择，可以帮助肥胖者减肥并降低CAD风险。本试验在clinicaltrials.gov上注册为UIC-004-2009。美国临床营养杂志2009; 90：1138-43。
Background: The ability of modified alternate-day fasting (ADF; ie, consuming 25% of energy needs on the fast day and ad libitum food intake on the following day) to facilitate weight loss and lower vascular disease risk in obese individuals remains unknown.Objective: This study examined the effects of ADF that is administered under controlled compared with self-implemented conditions on body weight and coronary artery disease (CAD) risk indicators in obese adults.Design: Sixteen obese subjects (12 women, 4 men) completed a 10-wk trial, which consisted of 3 phases: 1) a 2-wk control phase, 2) a 4-wk weight loss/ADF controlled food intake phase, and 3) a 4-wk weight loss/ADF self-selected food intake phase.Results: Dietary adherence remained high throughout the controlled food intake phase (days adherent: 86%) and the self-selected food intake phase (days adherent: 89%). The rate of weight loss remained constant during controlled food intake (0.67 +/- 0.1 kg/wk) and self-selected food intake phases (0.68 +/- 0.1 kg/wk). Body weight decreased (P < 0.001) by 5.6 +/- 1.0 kg (5.8 +/- 1.1%) after 8 wk of diet. Percentage body fat decreased (P < 0.01) from 45 +/- 2% to 42 +/- 2%. Total cholesterol, LDL cholesterol, and triacylglycerol concentrations decreased (P < 0.01) by 21 +/- 4%, 25 +/- 10%, and 32 +/- 6%, respectively, after 8 wk of ADF, whereas HDL cholesterol remained unchanged. Systolic blood pressure decreased (P < 0.05) from 124 +/- 5 to 116 +/- 3 mm Hg.Conclusion: These findings suggest that ADF is a viable diet option to help obese individuals lose weight and decrease CAD risk. This trial was registered at clinicaltrials.gov as UIC-004-2009. Am J Clin Nutr 2009; 90: 1138-43.