Divergent Hox Coding and Evasion of Retinoid Signaling Specifies Motor Neurons Innervating Digit Muscles.
Divergent Hox Coding and Evasion of Retinoid Signaling Specifies Motor Neurons Innervating Digit Muscles.
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DOI：
10.1016/j.neuron.2017.01.017
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发表时间：
2017-02-22
期刊：
影响因子：
16.2
通讯作者：
Jessell TM
中科院分区：
文献类型：
--
作者：
Mendelsohn AI;Dasen JS;Jessell TM
脊髓运动神经元亚类多样性的建立是通过与肢体肌肉目标组织相一致的发育计划来实现的。手指的进化出现代表了肢体形态的特殊适应，但仍不清楚支配手指的运动神经元亚型的规范如何与手指的精细化平行。我们表明，手指神经支配的运动神经元可以通过选择性基因标记来定义，并通过变异 Hox 基因库的表达和视黄酸合成中涉及的关键酶的表达失败来与其他 LMC 神经元区分开来。这种不同的发育程序足以诱导数字神经运动神经元的规范，强调数字控制在熟练运动行为进化中的特殊地位。我们的研究结果表明，肢体中手指的出现与指定支配手指肌肉的运动神经元的不同机制相匹配。
The establishment of spinal motor neuron subclass diversity is achieved through developmental programs that are aligned with the organization of muscle targets in the limb. The evolutionary emergence of digits represents a specialized adaptation of limb morphology, yet it remains unclear how the specification of digit-innervating motor neuron subtypes parallels the elaboration of digits. We show that digit-innervating motor neurons can be defined by selective gene markers and distinguished from other LMC neurons by the expression of a variant Hox gene repertoire and by the failure to express a key enzyme involved in retinoic acid synthesis. This divergent developmental program is sufficient to induce the specification of digit-innervating motor neurons, emphasizing the specialized status of digit control in the evolution of skilled motor behaviors. Our findings suggest that the emergence of digits in the limb is matched by distinct mechanisms for specifying motor neurons that innervate digit muscles.