Combinatorial control of Drosophila eye development by eyeless, homothorax, and teashirt
Combinatorial control of Drosophila eye development by eyeless, homothorax, and teashirt
复制标题
DOI：
10.1101/gad.1009002
复制
发表时间：
2002-09-15
影响因子：
10.5
通讯作者：
Mann, RS
中科院分区：
文献类型：
--
作者：
Bessa, J;Gebelein, B;Mann, RS
果蝇复眼的发育依赖于一条形态发生沟（MF）从眼盘后部（P）向前部（A）的移动。我们定义了几个子域沿着的A-P轴的眼盘，表达不同的转录因子的组合。位于MF之前的一个亚结构域表达两个同源异型盒基因，无眼基因（eyeless，ey）和同胸基因（homothorax，hth），以及锌指基因teashirt（tsh）。我们提供的证据表明，这种转录因子的组合可能作为一个复杂的功能，它至少在眼睛发育中起两个作用：它阻断眼睛发育级联中的后期作用转录因子的表达，它促进细胞增殖。在眼睛发育中，从不成熟的增殖状态向定型状态转变的关键步骤是BMP-4同源物Decapentaplegic（Dpp）对hth的抑制。
In Drosophila, the development of the compound eye depends on the movement of a morphogenetic furrow (MF) from the posterior (P) to the anterior (A) of the eye imaginal disc. We define several subdomains along the A-P axis of the eye disc that express distinct combinations of transcription factors. One subdomain, anterior to the MF, expresses two homeobox genes, eyeless (ey) and homothorax (hth), and the zinc-finger gene teashirt (tsh). We provide evidence that this combination of transcription factors may function as a complex and that it plays at least two roles in eye development: it blocks the expression of later-acting transcription factors in the eye development cascade, and it promotes cell proliferation. A key step in the transition from an immature proliferative state to a committed state in eye development is the repression of hth by the BMP-4 homolog Decapentaplegic (Dpp).