Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-κB in RAW 264.7 macrophages
Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-κB in RAW 264.7 macrophages
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DOI：
10.1016/s1567-5769(01)00110-2
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发表时间：
2001-09-01
影响因子：
5.6
通讯作者：
Chung, HT
中科院分区：
文献类型：
--
作者：
Pae, HO;Cho, H;Chung, HT
诱导型一氧化氮合酶（inducible NO synthase，iNOS）基因的激活导致大量一氧化氮（nitric oxide，NO）的产生，参与了炎症性疾病的发病机制。一种酚类化合物，Bakuchiol，分离自Pappea corylifolia L。（豆科植物）抑制用干扰素-γ和脂多糖激活的RAW 264.7巨噬细胞中的NO产生。机制研究表明，补骨脂素通过抑制核转录因子kappaB的表达而抑制iNOS mRNA的表达。因此，bakuchiol可能是一个有用的候选人，用于开发药物来治疗与iNOS基因过表达相关的炎症性疾病。(C)2001 Elsevier Science B. V.保留所有权利。
A large amount of nitric oxide (NO) production following the induction of inducible NO synthase (iNOS) gene has been implicated in the pathogenesis of inflammatory diseases. A phenolic compound, bakuchiol, isolated from Psoralea corylifolia L. (Leguminosae) inhibited NO production in RAW 264.7 macrophages activated with interferon-gamma and lipopolysaccharide. The mechanistic studies showed that bakuchiol inhibited the expression of iNOS mRNA through the inactivation of nuclear transcription factor-kappaB. Thus, bakuchiol may be a useful candidate for the development of a drug to treat inflammatory diseases related to iNOS gene over-expression. (C) 2001 Elsevier Science B.V. All rights reserved.