Guillain-Barre Syndrome, Influenza, and Influenza Vaccination: The Epidemiologic Evidence
Guillain-Barre Syndrome, Influenza, and Influenza Vaccination: The Epidemiologic Evidence
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DOI：
10.1093/cid/ciu005
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发表时间：
2014-04-15
影响因子：
11.8
通讯作者：
Broder, Karen
中科院分区：
文献类型：
--
作者：
Vellozzi, Claudia;Iqbal, Shahed;Broder, Karen
格林-巴利综合征（GBS）是世界范围内急性弛缓性麻痹最常见的原因，被认为是免疫介导的。大约三分之二的病例在上呼吸道或胃肠道感染之前发生，并与一些病毒感染有关，包括流感。GBS也与1976年的猪流感疫苗有关。此后，一些研究表明，在接受季节性和2009年H1N1单价流感疫苗后，GBS的风险略有增加。多年来的研究也显示，感染流感后患上格林-巴利综合征的风险会增加，其风险程度比接种流感疫苗后高出数倍。由于GBS是罕见的，接种疫苗后更是罕见，因此很难估计精确的风险。我们试图阐明过去35年来GBS的复杂关系及其与流感和流感疫苗的关系。
Guillain-Barre, syndrome (GBS) is the most common cause of acute flaccid paralysis worldwide, and is thought to be immune-mediated. It is preceded by upper respiratory or gastrointestinal infection in about two-thirds of cases and is associated with some viral infections, including influenza. GBS has also been associated with the 1976 swine-influenza vaccine. Thereafter, some studies have shown a small increased risk of GBS following receipt of seasonal and 2009 H1N1 monovalent influenza vaccines. Studies over the years have also shown an increased risk of GBS following influenza infection, and the magnitude of risk is several times greater than that following influenza vaccination. Because GBS is rare, and even rarer following vaccination, it is difficult to estimate precise risk. We try to shed light on the complex relationship of GBS and its association with influenza and influenza vaccines over the past 35 years.