Clinical Resting-state fMRI in the Preoperative Setting: Are We Ready for Prime Time?
Clinical Resting-state fMRI in the Preoperative Setting: Are We Ready for Prime Time?
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DOI：
10.1097/rmr.0000000000000075
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发表时间：
2016-02
期刊：
影响因子：
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通讯作者：
Shimony JS
中科院分区：
文献类型：
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作者：
Lee MH;Miller-Thomas MM;Benzinger TL;Marcus DS;Hacker CD;Leuthardt EC;Shimony JS
这篇文章的目的是介绍静息态功能磁共振成像（RS-fMRI），并利用我们研究所的丰富经验，回顾这种新的强大技术在术前的应用。RS-fMRI为脑生理学提供了重要的见解，并在临床环境中成为越来越重要的工具。与受试者在扫描时执行任务的基于任务的功能性MRI相反，RS-fMRI评估受试者休息时血氧水平依赖（BOLD）信号的低频波动。已经确定了多个静息状态网络（RSN），包括躯体感觉、语言和视觉网络，这些网络对于术前规划至关重要。在过去的4年中，我们已经进行了超过300 RS-fMRI检查在临床上设置，这些已被用来定位功能的躯体感觉和语言皮层脑肿瘤切除术前。RS-fMRI在这种情况下特别适用于无法与基于任务的范式合作的患者，例如幼儿或镇静剂，麻痹或失语症患者。虽然RS-fMRI仍在研究中，我们的经验表明，这种方法是准备在术前设置的临床应用。
The purpose of this manuscript is to provide an introduction to resting-state functional magnetic resonance imaging (RS-fMRI) and to review the current application of this new and powerful technique in the preoperative setting using our institute’s extensive experience. RS-fMRI has provided important insights into brain physiology and is an increasingly important tool in the clinical setting. As opposed to task-based functional MRI wherein the subject performs a task while being scanned, RS-fMRI evaluates low-frequency fluctuations in the blood oxygen level dependent (BOLD) signal while the subject is at rest. Multiple resting state networks (RSNs) have been identified, including the somatosensory, language, and visual networks, which are of primary importance for presurgical planning. Over the past 4 years, we have performed over 300 RS-fMRI examinations in the clinical setting and these have been used to localize eloquent somatosensory and language cortices before brain tumor resection. RS-fMRI is particularly useful in this setting for patients who are unable to cooperate with the task-based paradigm, such as young children or those who are sedated, paretic, or aphasic. Although RS-fMRI is still investigational, our experience indicates that this method is ready for clinical application in the presurgical setting.