The performance of expansile nanoparticles in a murine model of peritoneal carcinomatosis
The performance of expansile nanoparticles in a murine model of peritoneal carcinomatosis
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DOI：
10.1016/j.biomaterials.2010.09.059
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发表时间：
2011-01-01
期刊：
影响因子：
14
通讯作者：
Grinstaff, Mark W.
中科院分区：
文献类型：
--
作者：
Colson, Yolonda L.;Liu, Rong;Grinstaff, Mark W.
腹膜表面恶性肿瘤（如间皮瘤、阑尾癌或卵巢转移瘤）显着降低生存率和生活质量 鉴于间皮瘤手术减灭后局部复发率为 60-80%，目前的研究探索使用专门设计的聚合物纳米颗粒在内体 pH 值下扩展和局部递送化疗药物 负载紫杉醇的 pH 响应型可膨胀纳米粒子 (Pax-eNP) 的抗肿瘤功效在体外和体内恶性腹膜间皮瘤小鼠模型中进行了评估 Pax-eNP 在体外抑制间皮瘤生长，显着降低肿瘤生长和疾病严重程度，在体内预防初始 与其他腹膜内药物递送方法相比，腹膜内肿瘤植入并显着延长生存期这些结果表明，pH 触发的药物递送机制和与 eNP 相关的肿瘤亲和力可以有效改善局部侵袭性恶性肿瘤手术减灭后残留微观疾病的局部控制 (C) 2010 Elsevier Ltd 保留所有权利
Carcinomatosis from peritoneal surface malignancies such as mesothelioma appendiceal carcinoma or ovarian metastases significantly decreases survival and quality of life Given a 60-80% locoregional recurrence rate after surgical debulking for mesothelioma the current study explores the use of polymeric nanoparticles specifically engineered to expand and locally deliver chemotherapeutic agents at endosomal pH for the prevention of progressive carcinomatosis Anti-tumor efficacy of paclitaxel-loaded pH-responsive expansile nanoparticles (Pax-eNP) was evaluated in vitro and in in vivo murine models of malignant peritoneal mesothelioma Pax-eNP inhibited mesothelioma growth in vitro markedly decreased tumor growth and disease severity in vivo prevented initial intraperitoneal tumor implants and significantly prolonged survival compared to other intraperitoneal drug delivery methods These outcomes suggest that the mechanism of pH-triggered drug delivery and tumor affinity associated with eNP may effectively improve the local control of residual microscopic disease following surgical debulking of locoregionally aggressive malignancies (C) 2010 Elsevier Ltd All rights reserved