Corticostriatal pathways contribute to the natural time course of positive mood.
Corticostriatal pathways contribute to the natural time course of positive mood.
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DOI：
10.1038/ncomms10065
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发表时间：
2015-12-07
影响因子：
16.6
通讯作者：
Pizzagalli DA
中科院分区：
文献类型：
--
作者：
Admon R;Pizzagalli DA
情绪的自然时间进程既包括对刺激的剧烈反应，也包括自发波动。到目前为止，神经成像研究的重点要么是急性情感反应，要么是休息时的自发神经波动，但之前还没有研究同时探讨这两个组成部分，或者情绪障碍可能如何调节这些过程。在这里，使用功能磁共振成像，我们捕捉到了对自然主义积极情绪诱导的急性情感和神经反应，以及它们在休息状态下的自发波动。在健康对照组和有抑郁症病史的个体中，我们的操作显著提升了积极情绪和腹侧纹状体的激活。然而，只有对照组在一段时间内保持积极的情绪，而且在随后的休息期间，腹侧纹状体和内侧前额叶皮质之间出现了相互作用的关系。研究结果表明，皮质纹状体通路有助于积极情绪波动的自然时间进程，而这些神经相互作用的障碍可能是情绪障碍的特征。积极的情绪可以是刺激的结果，也可以是自发的。Admon和Pizzagalli测量了神经对积极刺激的反应随时间的变化，并确定了与持续积极情绪相关的皮质-纹状体相互作用，这些相互作用在有抑郁症病史的个人中会减少。
The natural time course of mood includes both acute responses to stimuli and spontaneous fluctuations. To date, neuroimaging studies have focused on either acute affective responses or spontaneous neural fluctuations at rest but no prior study has concurrently probed both components, or how mood disorders might modulate these processes. Here, using fMRI, we capture the acute affective and neural responses to naturalistic positive mood induction, as well as their spontaneous fluctuations during resting states. In both healthy controls and individuals with a history of depression, our manipulation acutely elevates positive mood and ventral striatum activation. Only controls, however, sustain positive mood over time, and this effect is accompanied by the emergence of a reciprocal relationship between the ventral striatum and medial prefrontal cortex during ensuing rest. Findings suggest that corticostriatal pathways contribute to the natural time course of positive mood fluctuations, while disturbances of those neural interactions may characterize mood disorder. Positive mood can occur as a result of a stimulus or spontaneously. Admon and Pizzagalli measure variations in neural responses to a positive stimulus over time, and identify cortico-striatal interactions associated with sustained positive mood which are reduced in individuals with a history of depression.