The Cytochrome P450 Engineering Database: a navigation and prediction tool for the cytochrome P450 protein family
The Cytochrome P450 Engineering Database: a navigation and prediction tool for the cytochrome P450 protein family
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DOI：
10.1093/bioinformatics/btm268
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发表时间：
2007-08-01
期刊：
影响因子：
5.8
通讯作者：
Pleiss, Juergen
中科院分区：
文献类型：
--
作者：
Fischer, Markus;Knoll, Michael;Pleiss, Juergen
细胞色素P450工程数据库（CYPED）旨在作为一种工具，在广泛和多样化的细胞色素P450单加氧酶（CYPs）家族中对蛋白质序列和结构进行全面和系统的比较。CYPED目前分别整合了3911和25个蛋白的序列和结构数据。根据尼尔森的分类，蛋白质分为同源家族和超家族。未分类的CYP序列按相似性分配。注释了功能相关残基。网络可访问的版本包含多序列比对，系统发育树和HMM配置文件。CYPED定期更新，并提供所有数据供下载。因此，它为系统发育分析、序列-功能关系研究和设计具有改进生化性能的CYPs提供了有价值的数据来源。
The Cytochrome P450 Engineering Database (CYPED) has been designed to serve as a tool for a comprehensive and systematic comparison of protein sequences and structures within the vast and diverse family of cytochrome P450 monooxygenases (CYPs). The CYPED currently integrates sequence and structure data of 3911 and 25 proteins, respectively. Proteins are grouped into homologous families and superfamilies according to Nelson's classification. Nonclassified CYP sequences are assigned by similarity. Functionally relevant residues are annotated. The web accessible version contains multisequence alignments, phylogenetic trees and HMM profiles. The CYPED is regularly updated and supplies all data for download. Thus, it provides a valuable data source for phylogenetic analysis, investigation of sequence-function relationships and the design of CYPs with improved biochemical properties.