Hierarchical auditory processing directed rostrally along the monkey's supratemporal plane.
Hierarchical auditory processing directed rostrally along the monkey's supratemporal plane.
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DOI：
10.1523/jneurosci.2267-10.2010
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发表时间：
2010-09-29
期刊：
影响因子：
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通讯作者：
Mishkin M
中科院分区：
文献类型：
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作者：
Kikuchi Y;Horwitz B;Mishkin M
连接解剖学证据表明，包含直听区A1、R和RT的听觉核心构成了听觉皮质处理的第一阶段，从核心向外进行前馈投射，首先到周围的听带，然后到视丘。相关证据还提出了这样一种可能性，即核心本身是连续组织的，从A1到R具有前馈投影，从R到RT具有进一步的投影，尽管馈送方向未知。我们假设，RT区与颞上平面(RSTP)的更多嘴部部分一起形成了起源于听觉核心区A1的嘴部定向刺激质量加工流的前延伸。在这里，我们分析了沿STP尾侧分布的三个不同扇区的单个神经元的听觉反应：I扇区，主要是A1区；II扇区，主要是RT区；以及III扇区，主要是RTP(顶顶区)，包括距离颞尖3 mm的皮质。无论是简单的还是复杂的，兴奋反应的平均起始潜伏期和对猴子叫声和其他声音的刺激选择性从扇区I到扇区III逐渐增加。此外，扇区I的细胞对其他声音的反应比对猴子叫声的放电频率高得多，而扇区II和III的细胞对这两种刺激类型的反应速率相同。结果模式支持这样的建议，即STP包含一个具有逐渐增加的刺激选择性的、以嘴为导向的、按等级组织的听觉处理流，并且该流从初级听觉区域延伸到颞极。
Connectional anatomical evidence suggests that the auditory core, containing the tonotopic areas A1, R, and RT, constitutes the first stage of auditory cortical processing, with feedforward projections from core outward, first to the surrounding auditory belt and then to the parabelt. Connectional evidence also raises the possibility that the core itself is serially organized, with feedforward projections from A1 to R and with further projections, though of unknown feed-direction, from R to RT. We hypothesized that area RT together with more rostral parts of the supratemporal plane (rSTP) form the anterior extension of a rostrally directed stimulus-quality processing stream originating in the auditory core area A1. Here we analyzed auditory responses of single neurons in three different sectors distributed caudorostrally along the STP: Sector I, mainly area A1; Sector II, mainly area RT; and Sector III, principally RTp (the rostrotemporal polar area), including cortex located 3 mm from the temporal tip. Mean onset latency of excitation responses and stimulus selectivity to monkey calls and other sounds, both simple and complex, increased progressively from Sector I to III. Also, whereas cells in Sector I responded with significantly higher firing rates to the ‘other’ sounds than to monkey calls, those in Sectors II and III responded at the same rate to both stimulus types. The pattern of results support the proposal that the STP contains a rostrally directed, hierarchically organized auditory processing stream, with gradually increasing stimulus selectivity, and that this stream extends from the primary auditory area to the temporal pole.