EFFECTS ON INGESTIVE BEHAVIOR IN RATS OF THE ALPHA-1-ADRENOCEPTOR AGONIST CIRAZOLINE
EFFECTS ON INGESTIVE BEHAVIOR IN RATS OF THE ALPHA-1-ADRENOCEPTOR AGONIST CIRAZOLINE
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DOI：
10.1016/0014-2999(92)90645-k
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发表时间：
1992-01-07
影响因子：
5
通讯作者：
WELLMAN, PJ
中科院分区：
文献类型：
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作者：
DAVIES, BT;WELLMAN, PJ
下丘脑室旁核(PVN)微量注射苯肾上腺素和苯丙醇胺等多种α-1肾上腺素能受体激动剂，可抑制大鼠摄食，提示该受体可能与已知的易化PVNα-2-肾上腺素能受体相反，参与调节摄食。在目前的实验中，我们研究了PVN内注射以及全身注射Crazoline对食物和水摄取的影响，Crazoline是一种高效的α1-肾上腺素能受体激动剂。在实验1中，PVN内微量注射Crazoline(0、3、6、12和24nmo1)抑制摄食量(ED50=23.4nmo1)，但对水摄入量没有显著影响。在实验2中，全身注射Crazoline(0、0.05、0.1、0.2、0.4 mg/kg)也显著抑制小鼠的摄食量(ED50=0.05 mg/kg i.p.)，但对摄食量的影响较小(ED50=0.22 mg/kg i.p.)。这项研究的结果以及我们之前的研究都有力地支持了这一观点，即大鼠下丘脑室旁核内的α1肾上腺素能受体可靠地抑制食物摄取。
Microinjections of various alpha-1-adrenoceptor agonists including phenylephrine and phenylpropanolamine into the paraventricular hypothalamic nucleus (PVN) suppress food intake in rats, suggesting that this receptor type might act in opposition to previously identified facilatory PVN alpha-2-adrenoceptors in the modulation of feeding. In the present experiments, we examine the effects on food and water intake of intra-PVN as well as systemic injection of cirazoline, a highly potent alpha-1-adrenoceptor agonist. In Experiment 1, intra-PVN microinjection of cirazoline (0, 3, 6, 12 and 24 nmol) suppressed food intake (ED50 = 23.4 nmol) without significant effects on water intake. In Experiment 2, systemic injection of cirazoline (0, 0.05, 0.1, 0.2, 0.4 mg/kg) also markedly suppressed food intake (ED50 = 0.05 mg/kg i.p.), with a less potent action on water intake (ED50 = 0.22 mg/kg i.p.). The results of this study as well as our previous investigations strongly support the notion that alpha-1-adrenoceptors within rat PVN act to reliably suppress food intake.