Fetal and early life growth and body mass index from birth to early adulthood in 1958 British cohort: longitudinal study
Fetal and early life growth and body mass index from birth to early adulthood in 1958 British cohort: longitudinal study
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DOI：
10.1136/bmj.323.7325.1331
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发表时间：
2001-12-08
影响因子：
--
通讯作者：
Manor, O
中科院分区：
文献类型：
--
作者：
Parsons, TJ;Power, C;Manor, O
目的探讨出生体重对出生后不同阶段体重指数的影响，以及在考虑潜在混杂因素后，这种关系是否持续;以及胎儿生长指标的作用（出生体重相对于父母体型）和儿童生长。设计1958年英国出生队列的纵向研究。设置英格兰，苏格兰，1958年3月3日至9日出生的所有单身人士（10683名参与者，数据在33岁时可用）。主要结果测量7岁、11岁、16岁、23岁和33岁时的体重指数。结果出生体重和体重指数之间的关系是正的和弱的，随着年龄的增长，J形越来越多。当对母亲体重进行调整时，出生体重和33岁时的博伊德质量指数之间没有关系。基于母亲体型的胎儿生长不良指标并不能预测，但在7岁时生长到最终成年身高的比例更大的参与者中，成年肥胖的风险更高。仅在男性中，儿童期生长的影响是最强的，在那些出生体重较低，在较小的程度上，那些出生于较轻的mother.Conclusions母亲体重（或体重指数）在很大程度上解释了出生体重和成人体重指数之间的关联，它可能是一个更重要的危险因素，肥胖的孩子比出生体重。出生体重和母亲体重似乎改变了儿童期线性生长对成年男性肥胖的影响。母亲和其后代的身体质量指数之间的代际关联似乎是出生体重和身体质量指数之间有据可查的关联的基础。为了更全面地了解宫内环境在肥胖发展中的作用，需要其他胎儿生长指标。
Objectives To determine the influence of birth weight on body mass index at different stages of later life; whether this relation persists after accounting for potential confounding factors; and the role of indicators of fetal growth (birth weight relative to parental size) and childhood growth.Design Longitudinal study of the 1958 British birth cohort.Setting England, Scotland, and Wales.Participants All singletons born 3-9 March 1958 (10 683 participants with data available at age 33).Main outcome measures Body mass index at ages 7, 11, 16, 23, and 33 years.Results The relation between birth weight and body mass index was positive and weak, becoming more J shaped with increasing age. When adjustments were made for maternal weight, there was no relation between birth weight and boyd mass index at age 33. Indicators of poor fetal growth based on the mother's body size were not predictive, but the risk of adult obesity was higher among participants who had grown to a greater proportion of their eventual adult height by age 7. In men only, the effect of childhood growth was strongest in those with lower birth weights and, to a lesser extend, those born to lighter mothers.Conclusions Maternal weight (or body mass index) largely explains the association between birth weight and adult body mass index, and it may be a more important risk factor for obesity in the child than birth weight. Birth weight and maternal weight seem to modify the effect of childhood linear growth on adult obesity in men. Intergenerational associations between the mother's and her offspring's body mass index seem to underlie the well documented association between birth weight and body mass index. Other measures of fetal growth are needed for a fuller understanding of the role of the intrauterine environment in the development of obesity.