The relative gastrointestinal toxicity of the nonsteroidal anti-inflammatory drugs.
The relative gastrointestinal toxicity of the nonsteroidal anti-inflammatory drugs.
复制标题
非甾体类抗炎药的相对胃肠道毒性。
DOI：
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发表时间：
1987
影响因子：
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通讯作者：
Judith K. Jones
中科院分区：
文献类型：
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作者：
Jeffrey L. Carson;Brian L. Strom;M. Morse;Suzanne L. West;Keith A. Soper;P. Stolley;Judith K. Jones;Judith K. Jones
为了评估与非甾体抗炎药（NSAID）相关的上消化道（UGI）出血的相对发生率，我们使用密歇根州和明尼苏达州所有医疗补助患者的1980份账单数据进行了一项回顾性队列研究。在88，044名仅分发了7种NSAID中的一种的患者中，检查了每次药物暴露后30天内的UGI道出血率。这些药物的使用者之间的上消化道出血率差异显着。分层和逻辑回归用于调整多个潜在的混杂因素，结果无实质性变化。酒精与药物的相互作用被发现，舒林酸使用者的上消化道出血率最高，它是唯一一种与布洛芬有统计学差异的药物。当接受的舒林酸平均日剂量除以最大推荐日剂量时，它明显高于其他药物。使用1982年的数据进行的重复分析证实了这些结果。我们的结论是，在这一人群中，与使用NSAID相关的上消化道出血的发生率存在显著且一致的差异。
To assess the relative rate or upper gastrointestinal (UGI) tract bleeding associated with nonsteroidal anti-inflammatory drugs (NSAIDs), we performed a retrospective cohort study using 1980 billing data from all Medicaid patients in the states of Michigan and Minnesota. The rate of UGI tract bleeding in the 30 days following each drug exposure was examined in the 88,044 patients dispensed only one of seven NSAIDs. The rate of UGI tract bleeding differed significantly among users of these drugs. Stratification and logistic regression were used to adjust for multiple potential confounding factors, without substantive changes in the results. An alcohol-drug interaction was found. Sulindac users had the highest rate of UGI tract bleeding, and it was the only drug statistically different from ibuprofen. When the average daily dose of sulindac received was divided by the maximum recommended daily dose, it was notably higher than those for other drugs. Repeated analyses using data from 1982 confirmed these results. We conclude that there are significant and consistent differences in the incidence of UGI tract bleeding associated with the use of NSAIDs in this population.