Interaction Effects of Season of Birth and Cytokine Genes on Schizotypal Traits in the General Population.
Interaction Effects of Season of Birth and Cytokine Genes on Schizotypal Traits in the General Population.
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DOI：
10.1155/2017/5763094
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发表时间：
2017
影响因子：
2.4
通讯作者：
Golimbet VE
中科院分区：
文献类型：
--
作者：
Alfimova MV;Korovaitseva GI;Lezheiko TV;Golimbet VE
文献提示，冬季出生对精神分裂症易感性的影响可能与产前感染导致的促炎细胞因子表达增加以及抗炎因子调节不足有关。由于免疫系统的反应依赖于基因型，本研究通过分裂型人格问卷（SPQ-74）评估细胞因子基因和出生季节（SOB）对分裂型的相互作用。我们在278名健康个体的样本中寻找IL1B rs16944、IL4 rs2243250和IL-1RN VNTR多态性、SOB及其与SPQ-74总分的相互作用的关联。il - 4与SOB相互作用的影响显著，p = 0.007, η2 = 0.028。我们通过373个人的扩展样本证实了这一效应。冬季出生的纯合子CC的SPQ总分最高，与冬季出生的T等位基因携带者差异显著（p = 0.049）。这种差异在认知-知觉和无组织维度上得到了证明，但在人际关系维度上没有。这些发现与细胞因子基因通过SOB相互作用可以影响一般人群中分裂型性状的变异性的假设是一致的。在冬季出生的个体中，il4t等位基因似乎对阳性和无序分裂型性状的发展具有保护作用。
Literature suggests that the effect of winter birth on vulnerability to schizophrenia might be mediated by increased expression of proinflammatory cytokines due to prenatal infection and its inadequate regulation by anti-inflammatory factors. As the response of the immune system depends on genotype, this study assessed the interaction effects of cytokine genes and season of birth (SOB) on schizotypy measured with the Schizotypal Personality Questionnaire (SPQ-74). We searched for associations of IL1B rs16944, IL4 rs2243250, and IL-1RN VNTR polymorphisms, SOB, and their interactions with the SPQ-74 total score in a sample of 278 healthy individuals. A significant effect of the IL4 X SOB interaction was found, p = 0.007 and η2 = 0.028. We confirmed this effect using an extended sample of 373 individuals. Homozygotes CC born in winter showed the highest SPQ total score and differed significantly from winter-born T allele carriers, p = 0.049. This difference was demonstrated for cognitive-perceptual and disorganized but not interpersonal dimensions. The findings are consistent with the hypothesis that the cytokine genes by SOB interaction can influence variability of schizotypal traits in the general population. The IL4 T allele appeared to have a protective effect against the development of positive and disorganized schizotypal traits in winter-born individuals.