Maternal antibodies to rotavirus: Could they interfere with live rotavirus vaccines in developing countries?
Maternal antibodies to rotavirus: Could they interfere with live rotavirus vaccines in developing countries?
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DOI：
10.1016/j.vaccine.2010.11.087
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发表时间：
2011-02-01
期刊：
影响因子：
5.5
通讯作者：
Danchin, M. D.
中科院分区：
文献类型：
--
作者：
Chan, J.;Nirwati, H.;Danchin, M. D.
简介：过去口服活疫苗（包括获得许可的轮状病毒疫苗）的经验表明，与发达国家相比，发展中国家的疫苗效力有下降的趋势。这种差异背后的原因尚不清楚。在轮状病毒感染流行且母体抗体水平较高的发展中国家，母体抗体的经胎盘转移和母乳摄入可能会减弱婴儿的疫苗应答。我们研究了轮状病毒抗体的患病率和水平在孕产妇和脐带血清，初乳和母乳在一个发展中国家setting.Methods：100对母婴前瞻性招募2008年12月至2009年2月在Sardjito博士医院，日惹，印度尼西亚。在分娩期间收集母体和脐带血清。分别于产后0-3天和7-10天采集初乳和过渡期母乳。轮状病毒特异性伊加和IgG估计所有标本和病毒中和试验进行了一个子集的牛奶samples.Results：所有产妇和脐带血清样本的轮状病毒特异性IgG抗体呈阳性，轮状病毒特异性IgG抗体的母亲和水平之间的强相关性转移到婴儿脐带血（r = 0.86，p = 0.001）。78%的初乳和67%的过渡期母乳标本轮状病毒特异性伊加阳性。有一个中位数为4倍的下降轮状病毒特异性伊加从初乳过渡母乳中和抗体存在于56%的初乳标本测定（19/34），并在41%的过渡乳标本测定（14/34）。结论：产妇血清和母乳抗体轮状病毒是非常普遍的发展中国家设置。评价母亲抗轮状病毒血清和母乳抗体对疫苗免疫原性的影响将有助于为轮状病毒疫苗接种策略提供信息，特别是在发展中国家。(C)2010爱思唯尔有限公司保留所有权利。
Introduction: Past experience with live oral vaccines including licensed rotavirus vaccines demonstrates a trend towards reduced vaccine efficacy in developing countries compared with developed countries. The reasons behind this disparity are not well understood. Transplacental transfer of maternal antibodies and breast milk ingestion may attenuate vaccine responses in infants in developing countries where rotavirus infections are endemic, and maternal antibody levels are high. We examined the prevalence and level of rotavirus antibody in maternal and cord serum, colostrum and breast milk in a developing country setting.Methods: 100 mother-infant pairs were prospectively recruited from December 2008 to February 2009 at Dr. Sardjito Hospital, Yogyakarta, Indonesia. Maternal and cord sera were collected during delivery. Colostrum and transitional breast milk were collected between day 0-3 and day 7-10 postpartum respectively. Rotavirus-specific IgA and IgG were estimated for all specimens and virus neutralization assays were conducted on a subset of milk specimens.Results: All maternal and cord serum samples were positive for rotavirus-specific IgG antibodies with a strong correlation between levels of rotavirus-specific IgG in mothers and levels transferred to infants in cord blood (r = 0.86; p = 0.001). 78% of colostrum and 67% of transitional breast milk specimens were positive for rotavirus-specific IgA. There was a median 4-fold decrease in rotavirus-specific IgA from colostrum to transitional breast milk Neutralizing antibodies were present in 56% of colostrum specimens assayed (19/34) and in 41% of transitional milk specimens assayed (14/34).Conclusions: Maternal serum and breast milk antibodies to rotavirus are highly prevalent in a developing country setting. Evaluation of the impact of maternal anti-rotavirus serum and breast milk antibody upon vaccine immunogenicity would help to inform rotavirus vaccination strategies, especially in developing settings. (C) 2010 Elsevier Ltd. All rights reserved.