Mesencephalic astrocyte-derived neurotrophic factor is involved in inflammation by negatively regulating the NF-κB pathway.
Mesencephalic astrocyte-derived neurotrophic factor is involved in inflammation by negatively regulating the NF-κB pathway.
复制标题
中脑星形胶质细胞衍生的神经营养因子通过负向调节 NF-κ B 通路参与炎症
DOI：
10.1038/srep08133
复制
发表时间：
2015-02-02
影响因子：
4.6
通讯作者：
Shen Y
中科院分区：
文献类型：
--
作者：
Chen L;Feng L;Wang X;Du J;Chen Y;Yang W;Zhou C;Cheng L;Shen Y;Fang S;Li J;Shen Y
Inflammation can cause endoplasmic reticulum (ER) stress and therefore activates the unfolded protein response (UPR). ER stress and the consequent UPR have the potential to activate NF-κB. However, the factors mediating the crosstalk between ER stress and the NF-κB pathway remain unclear. Here, we determined that ER stress inducible protein Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) was up-regulated in autoimmune diseases and inflammatory disease models. Inflammation caused MANF to relocalize to the nuclei. MANF interacted with the DNA binding domain of p65 through its C-terminal SAP-like domain in the nuclei under the condition of inflammation or ER stress. MANF consequently inhibited p65-mediated transcriptional activation by interfering with the binding of p65 to its target genes promoters. Consistently, MANF suppressed the expressions of NF-κB-dependent target genes and the proliferation of inflammatory synoviocytes. These findings suggest that MANF may be a negative regulator of inflammation and mediate the crosstalk between the NF-κB pathway and ER stress.
登录
查看更多内容
活化的巨噬细胞样滑膜细胞对抗原诱导的关节炎中内质网应激诱导的细胞凋亡具有抵抗力
影响因子：
6.7
作者：
Feng, Li-Jie;Jiang, Tong-Cui;Shen, Yu-Xian
通讯作者：
Shen, Yu-Xian
影响因子：
4.4
作者：
Hayakawa, Kunihiro;Hiramatsu, Nobuhiko;Kitamura, Masanori
通讯作者：
Kitamura, Masanori
影响因子：
2
作者：
Kaneko, M;Niinuma, Y;Nomura, Y
通讯作者：
Nomura, Y
影响因子：
2.7
作者：
Chen, Y. -C.;Sundvik, M.;Panula, P.
通讯作者：
Panula, P.
神经胶质细胞中中脑星形胶质细胞源性神经营养因子的上调与缺血诱导的神经胶质活化有关
影响因子：
9.3
作者：
Shen Y;Sun A;Wang Y;Cha D;Wang H;Wang F;Feng L;Fang S;Shen Y
通讯作者：
Shen Y