Registration-based approach for reconstruction of high-resolution in utero fetal MR brain images
Registration-based approach for reconstruction of high-resolution in utero fetal MR brain images
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DOI：
10.1016/j.acra.2006.05.003
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发表时间：
2006-09-01
影响因子：
4.8
通讯作者：
Studholme, Colin
中科院分区：
文献类型：
--
作者：
Rousseau, Francois;Glenn, Orit A.;Studholme, Colin
基本原理和目标。本文描述了一种形成人类胎儿大脑高分辨率 MR 图像的新方法。它通过提出将目前用于临床研究的多组正交快速二维 MRI 切片进行配准精细复合成单个高分辨率 MRI 体积来解决胎儿运动的关键问题。材料和方法。稳健的多分辨率切片对齐迭代地应用于数据，以纠正二维采集之间发生的胎儿运动。这与强度校正步骤和超分辨率重建步骤相结合，形成胎儿大脑的单个高各向同性分辨率体积。结果。包括对具有已知运动类型和基础解剖结构的合成图像数据的实验验证，以及对临床采集集的回顾性应用。结论。结果表明，该方法有望提供一种独特的途径来获取胎儿大脑体内的高分辨率 MRI，其质量可与新生儿 MRI 相当。这些数据为了解正常和异常大脑发育过程提供了一个非常有价值的窗口，可直接应用于临床环境。
Rationale and Objectives. This paper describes a novel approach to forming high-resolution MR images of the human fetal brain. It addresses the key problem of fetal motion by proposing a registration-refined compounding of multiple sets of orthogonal fast two-dimensional MRI slices, which are currently acquired for clinical studies, into a single high-resolution MRI volume.Materials and Methods. A robust multiresolution slice alignment is applied iteratively to the data to correct motion of the fetus that occurs between two-dimensional acquisitions. This is combined with an intensity correction step and a super-resolution reconstruction step, to form a single high isotropic resolution volume of the fetal brain.Results. Experimental validation on synthetic image data with known motion types and underlying anatomy, together with retrospective application to sets of clinical acquisitions, are included.Conclusion. Results indicate that this method promises a unique route to acquiring high-resolution MRI of the fetal brain in vivo allowing comparable quality to that of neonatal MRI. Such data provide a highly valuable window into the process of normal and abnormal brain development, which is directly applicable in a clinical setting.