Elevated levels of 8-iso-prostaglandin F2α in pericardial fluid of patients with heart failure -: A potential role for in vivo oxidant stress in ventricular dilatation and progression to heart failure
Elevated levels of 8-iso-prostaglandin F2α in pericardial fluid of patients with heart failure -: A potential role for in vivo oxidant stress in ventricular dilatation and progression to heart failure
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DOI：
10.1161/01.cir.97.16.1536
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发表时间：
1998-04-28
期刊：
影响因子：
37.8
通讯作者：
Tedgui, A
中科院分区：
文献类型：
--
作者：
Mallat, Z;Philip, I;Tedgui, A
背景--氧化应激可能在心力衰竭的病理生理学中发挥作用。方法和结果：为了评估心脏中的氧化应激，我们测量了51例连续接受心脏手术的缺血性心脏病和/或瓣膜病患者心包液中8-异前列腺素F-2α(8-iso-PGF(2α))的水平，8-iso-PGF(2α)是氧化应激的特异性和定量标记物。心包8-iso-PGF(2α)水平与心力衰竭的功能严重程度(NYHA分级)和独立医生测量的心脏扩大的超声心动图指数相关。有症状心力衰竭患者心包组织中8-iso-PGF(2α)水平较无症状心力衰竭患者显著升高，并随着心力衰竭功能严重程度的加重而逐渐升高(P=.0003)。此外，心包内8-iso-PGF(2α)水平与左心室舒张末和收缩末期内径显著相关(P分别为0.008和0.026)。结论：心包内8-iso-PGF(2α)水平随着心力衰竭的严重程度而增加，并与心室扩张有关。这些数据表明，体内氧化应激在心室重塑和心力衰竭的进展中起着重要作用。
Background-It has been suggested that oxidant stress may play a role in the pathophysiology of heart failure. However, no definitive information is available because most previous approaches used to measure oxidant stress are nonspecific, inaccurate, and unreliable.Methods and Results-To evaluate oxidant stress in the heart, we measured pericardial fluid levels of 8-iso-prostaglandin F-2 alpha (8-iso-PGF(2 alpha)), a specific and quantitative marker of oxidant stress in vivo, in a series of 51 consecutive patients with ischemic and/or valvular heart disease referred for cardiac surgery. Pericardial levels of 8-iso-PGF(2 alpha) were correlated with the functional severity of heart failure (NYHA classification) and with echocardiographic indices of ventricular dilatation measured by independent physicians. Pericardial levels of 8-iso-PGF(2 alpha) were significantly increased in patients with symptomatic heart failure compared with asymptomatic patients and gradually increased with the functional severity of heart failure (P=.0003). In addition, pericardial levels of 8-iso-PGF(2 alpha) were significantly correlated with left ventricular end-diastolic and end-systolic diameters (P=.008 and .026, respectively).Conclusions-Pericardial levels of 8-iso-PGF(2 alpha) increase with the functional severity of heart failure and are associated with ventricular dilatation. These data suggest an important role for in vivo oxidant stress on ventricular remodeling and the progression to heart failure.