Flow chemistry remains an opportunity for chemists and chemical engineers
Flow chemistry remains an opportunity for chemists and chemical engineers
复制标题
DOI：
10.1016/j.coche.2020.05.002
复制
发表时间：
2020-09-01
影响因子：
6.6
通讯作者：
Hartman, Ryan L.
中科院分区：
文献类型：
--
作者：
Hartman, Ryan L.
近年来，流动化学从有机合成化学的基本实验室技术发展到实践中的复杂多步骤过程，取得了相当大的进展。在这方面的审查，缺失的环节，代表化学家和化学工程师的机会进行检查。反应化学的新途径正在扩大分子工具箱，其中包括绿色和级联催化。机器智能和可持续制造等下一代工程概念已成为现实，为跨学科工作打开了前所未有的大门。还强调了有可能启动新的研究和技术进步领域的新趋势。流动化学正在改写传统的化学实验室和我们的科学发现基础设施。巨大的机会仍然是开创性的科学和工程从这个令人兴奋的领域，需要训练有素的劳动力，其工业实践。现在正在为未来的工业奠定基础，如连续流生物制剂，生物制药和纳米材料革命的实施。
Flow chemistry has progressed considerably in recent years from basic laboratory techniques in organic synthetic chemistry to complex, multistep processes in practice. In this perspective review, missing links that represent opportunities for chemists and chemical engineers are examined. New avenues in reaction chemistry are expanding the molecular toolbox, which includes green and cascade catalysis. Next generation engineering concepts such as machine intelligence and sustainable manufacturing have become a reality, opening the door to interdisciplinary work unlike before. Emerging trends that have the potential to start new fields of research and technological advancements are also highlighted. Flow chemistry is rewriting the traditional chemistry laboratory and our scientific discovery infrastructure. Enormous opportunities remain for groundbreaking science and engineering from this exciting field that demands a well-trained workforce for its industrial practice. The groundwork is being laid now for industries of the future such as continuous-flow biologics, biopharmaceuticals, and implementation of the nanomaterials revolution.