Facile preparation of self-assembled hydrogel-like GdPO4•H2O nanorods
Facile preparation of self-assembled hydrogel-like GdPO4•H2O nanorods
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DOI：
10.1021/la800847d
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发表时间：
2008-08-05
期刊：
影响因子：
3.9
通讯作者：
Yeh, Chen-Sheng
中科院分区：
文献类型：
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作者：
Huang, Chih-Chia;Lo, Yi-Wei;Yeh, Chen-Sheng
在制备一维磷酸镧（LnPO(4)）纳米棒/纳米线（如GdPO4）的方法中，水热法一直是主要的合成途径。在本研究中，我们报告了一种简单的低温溶液制备GdPO4中心点H2O纳米棒的方法，只需在88℃下将GdCl3和KH2PO4回流15分钟，这种方法可以通过增加试剂量来扩大规模。我们将制备好的GdPO4中心点H2O纳米材料与H2O混合，观察到一种高粘性的宏观水凝胶状材料。水凝胶是一类重要的生物材料。它们的构建块通常由蛋白质、肽、聚合物和脂质材料构成，为药物输送、组织工程和生物传感器提供了三维支架。我们的初步结果表明，GdPO4-H2O水凝胶可用于包封和药物释放，并且具有生物相容性，可作为促进细胞增殖的支架。这些发现表明它们可能具有生物医学用途。我们的发现可能会导致其他无机纳米材料为基础的水凝胶除了有机和生物分子蛋白质，肽，聚合物和脂质为基础的构建模块的创建。
Of the methods employed in the preparation of one-dimensional lanthanide phosphate (LnPO(4)) nanorods/nanowires, such as GdPO4, the hydrothermal method has been mainly used as a synthetic route. In this Study, we report a facile low-temperature solution approach to prepare GdPO4 center dot H2O nanorods by simply refluxing GdCl3 and KH2PO4 for only 15 min at 88 degrees C, an approach that can easily be scaled up by increasing the reagent amounts. We observed a highly viscous macroscopic hydrogel-like material when we mixed as-prepared GdPO4 center dot H2O nanomaterials with H2O. Hydrogels are an important class of biomaterials. Their building blocks, normally formed from protein-, peptide-, polymer-, and lipid-based materials, offer three-dimensional scaffolds for drug delivery, tissue engineering, and biosensors. Our preliminary results showed that GdPO4-H2O hydrogels could be used for encapsulation and drug release, and that they were biocompatible, acting as scaffolds to foster cell proliferation. These findings suggested that they might have biomedical uses. Our findings may lead to the creation of other inorganic nanomaterial-based hydrogels apart from the organic and biomolecular protein-, peptide-, polymer-, and lipid-based building blocks.