Frontal white matter changes and aggression in methamphetamine dependence
Frontal white matter changes and aggression in methamphetamine dependence
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DOI：
10.1007/s11011-015-9775-9
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发表时间：
2016-02-01
影响因子：
3.6
通讯作者：
Uhlmann, Anne
中科院分区：
文献类型：
--
作者：
Lederer, Katharina;Fouche, Jean-Paul;Uhlmann, Anne
长期使用甲基苯丙胺（MA）可导致白色物质（WM）变化和攻击性水平增加。虽然以前的研究已经检查了与认知障碍有关的WM异常，但WM完整性和MA依赖中的攻击性之间的关联仍不清楚。应用扩散张量成像（DTI）技术，对40例MA依赖者和40例健康对照者的WM改变进行了研究。在FSL中使用基于束的空间统计（TBSS）的感兴趣区域（ROI）方法进行。我们比较了分数各向异性（FA），平均扩散率（MD），平行扩散率（λ（一个中心点））和垂直扩散率（λ（a“'）在额叶脑WM束。研究了工作记忆与Buss &佩里问卷中攻击性得分的关系。与对照组相比，MA组的愤怒（p < 0.001）、身体攻击（p = 0.032）和总攻击（p = 0.021）的平均得分显著更高。ROI分析显示，在MA依赖性中，胼胝体内侧的MD（U = 439.5，p = 0.001）和lambda（a“'）（U = 561.5，p = 0.021）值增加，右侧扣带的MD（U = 541.5，p = 0.012）值增加。没有WM的变化与攻击性得分显着相关。这项研究提供了证据，额叶WM的变化和增加的攻击水平的个人与MA依赖。WM和攻击行为之间缺乏显着的关联可能反映了测量这种行为的方法学问题，或者可能表明攻击的神经生物学不仅仅与WM损伤相关，而是更复杂。
Chronic methamphetamine (MA) use can lead to white matter (WM) changes and increased levels of aggression. While previous studies have examined WM abnormalities relating to cognitive impairment, associations between WM integrity and aggression in MA dependence remain unclear. Diffusion Tensor Imaging (DTI) was used to investigate WM changes in 40 individuals with MA dependence and 40 matched healthy controls. A region of interest (ROI) approach using tract based spatial statistics (TBSS) in FSL was performed. We compared fractional anisotropy (FA), mean diffusivity (MD), parallel diffusivity (lambda(a center dot)) and perpendicular diffusivity (lambda(a"')) in WM tracts of the frontal brain. A relationship of WM with aggression scores from the Buss & Perry Questionnaire was investigated. Mean scores for anger (p < 0.001), physical aggression (p = 0.032) and total aggression (p = 0.021) were significantly higher in the MA group relative to controls. ROI analysis showed increased MD (U = 439.5, p = 0.001) and lambda(a"') (U = 561.5, p = 0.021) values in the genu of the corpus callosum, and increased MD (U = 541.5, p = 0.012) values in the right cingulum in MA dependence. None of the WM changes were significantly associated with aggression scores. This study provides evidence of frontal WM changes and increased levels of aggression in individuals with MA dependence. The lack of significant associations between WM and aggressive behaviour may reflect methodological issues in measuring such behaviour, or may indicate that the neurobiology of aggression is not simply correlated with WM damage but is more complex.