How Ca2+-ATPase pumps ions across the sarcoplasmic reticulum membrane.
How Ca2+-ATPase pumps ions across the sarcoplasmic reticulum membrane.
复制标题
DOI：
10.1016/j.bbamcr.2008.10.008
复制
发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
C. Toyoshima
中科院分区：
文献类型：
--
作者：
C. Toyoshima
肌浆网的Ca 2 +-ATP酶是一种ATP驱动的Ca 2+泵，可跨膜建立> 10，000倍的浓度梯度。它的晶体结构已被确定为9个不同的状态，几乎涵盖了整个反应周期。这里提出的是一个简短的结构帐户的离子泵的过程中，强调为什么结构必须如此。
Ca2+-ATPase of muscle sarcoplasmic reticulum is an ATP-powered Ca2+-pump that establishes a >10,000 fold concentration gradient across the membrane. Its crystal structures have been determined for 9 different states that cover nearly the entire reaction cycle. Presented here is a brief structural account of the ion pumping process, with emphasis on why the structure has to be so.