Highly active antiretroviral therapy reduces pulmonary IL-8 in HIV-positive women smokers.
Highly active antiretroviral therapy reduces pulmonary IL-8 in HIV-positive women smokers.
复制标题
高效抗逆转录病毒疗法可降低 HIV 阳性女性吸烟者的肺部 IL-8。
DOI：
10.1093/femspd/ftv115
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发表时间：
2016
影响因子：
3.3
通讯作者：
Garzino-Demo,Alfredo
中科院分区：
文献类型：
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作者：
Taylor,GregoryH;Williams,AdrienneA;Garzino-Demo,Alfredo
在慢性阻塞性肺疾病（COPD）患者的痰液中以及在HIV感染的病理性肺部表现期间检测到促炎细胞因子IL-8水平升高。为了探讨吸烟、高效抗逆转录病毒治疗（HAART）和HIV免疫状态之间的潜在相互关系，我们收集了痰液样本，沿着的是对接受或未接受HAART的HIV感染女性吸烟者进行的完整肺功能测试。对患者痰液进行细胞计数沿着IL-8定量测量分析，并与肺功能试验（PFT）的同时评估相关。我们发现，HIV阳性吸烟者的肺一氧化碳弥散量（DLCO）的PFT测量值与标准参考值相比有所降低，而标准参考值与HAART使用无差异。HAART在控制CD 4时，对痰液中促炎细胞因子IL-8的水平显示出抑制作用。我们的结论是，在HAART时代，艾滋病毒沿着同时吸烟与艾滋病毒感染妇女的PFT下降有关。在患者中使用HAART似乎减轻了与基于CD 4计数的免疫状态相关的IL-8水平的增加。
Increased levels of the proinflammatory cytokine IL-8 are detected in the sputum of patients with chronic obstructive pulmonary disease (COPD) and during the pathological pulmonary manifestations of HIV infection.To explore a potential interrelationship between smoking, highly active antiretroviral therapy (HAART) and HIV immune status, we collected sputum samples, along with complete pulmonary function tests from groups of HIV-infected women smokers who were either on or off HAART. Analysis of the patient's sputum for cell count along with quantitative measures of IL-8 was performed and correlated with concurrent assessment of pulmonary function test (PFT). We found that HIV-positive smokers had decreased measurements on PFT of the diffusing capacity of the lung for carbon monoxide (DLCO) compared to standard reference values that did not differ with HAART usage. HAART, when controlled for CD4, showed a suppressive effect on the levels of pro inflammatory cytokine IL-8 in sputum. We conclude that in the era of HAART, HIV along with concurrent tobacco smoking is associated with declines in PFT in HIV-infected women. The use of HAART in patients appears to mitigate the increases in IL-8 levels in relation to immune status based on CD4 count.