Salvia miltiorrhiza: Traditional medicinal uses, chemistry, and pharmacology
Salvia miltiorrhiza: Traditional medicinal uses, chemistry, and pharmacology
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丹参：传统医学用途、化学和药理学
DOI：
10.1016/s1875-5364(15)30002-9
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发表时间：
2015-03-01
影响因子：
4.6
通讯作者：
Qin Lu-Ping
中科院分区：
文献类型：
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作者：
Su Chun-Yan;Ming Qian-Liang;Qin Lu-Ping
丹参（Salvia miltiorrhiza Bunge，SM）是一种非常受欢迎的药用植物，多年来被广泛应用于治疗各种疾病，特别是冠心病和脑血管疾病，无论是单独使用还是与其他植物性中药组合使用。尽管已经进行了大量关于SM的研究，但它们分散在各种出版物中。本文就SM的传统用途、化学成分、药理作用、毒副作用及药物相互作用等方面的最新研究进展进行综述，为SM的进一步研究和开发利用奠定基础。SM含有多种化学成分，包括二萜类醌、亲水性酚酸和精油。在过去的30年中，对SM进行了大量的药理学研究，主要集中在心脑血管作用，以及抗氧化、神经保护、抗纤维化、抗炎和抗炎活性。研究结果有力地支持了SM具有有益的治疗特性并且具有成为有效的适应性疗法的潜力的概念。
Salvia miltiorrhiza Bunge (SM) is a very popular medicinal plant that has been extensively applied for many years to treat various diseases, especially coronary heart diseases and cerebrovascular diseases, either alone or in combination with other Chinese plant-based medicines. Although a large number of studies on SM have been performed, they are scattered across a variety of publications. The present review is an up-to-date summary of the published scientific information about the traditional uses, chemical constituents, pharmacological effects, side effects, and drug interactions with SM, in order to lay the foundation for further investigations and better utilization of SM. SM contains diverse chemical components including diterpenoid quinones, hydrophilic phenolic acids, and essential oils. Many pharmacological studies have been done on SM during the last 30 years, focusing on the cardiovascular and cerebrovascular effects, and the antioxidative, neuroprotective, antifibrotic, anti-inflammatory, and antineoplastic activities. The research results strongly support the notion that SM has beneficial therapeutic properties and has a potential of being an effective adaptogenic remedy.