Biocompatible, micro- and nano-fabricated magnetic cylinders for potential use as contrast agents for magnetic resonance imaging
Biocompatible, micro- and nano-fabricated magnetic cylinders for potential use as contrast agents for magnetic resonance imaging
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DOI：
10.1016/j.snb.2014.01.096
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发表时间：
2014-06-01
影响因子：
8.4
通讯作者：
Zhang, Xin
中科院分区：
文献类型：
--
作者：
Wang, Congshun;Wang, Xiaoning;Zhang, Xin
本文报道了新的MEMS和NEMS为基础的生物相容性，空心圆柱形铁磁结构的制造工艺，作为磁共振成像（MRI）的造影剂的潜在用途。与以前的工作相比，镍基圆柱形纳米壳和铁基双盘颗粒，生物相容性和产量的问题，强烈考虑在此开发的一个简化的制造工艺，结合氧化铁薄膜。本文开发的新型简化制造工艺为进一步开发这类新型MRI造影剂提供了稳健、可重复的制造方法。具体而言，微米和纳米尺度的中空圆柱形代理成功地制造，其大小制度，使广泛的潜在的成像应用。使用自上而下的工程方法来设计MRI造影剂，如本文所报道的，提供了多路成像的能力，这可以显著地增强MRI成像的能力。(C)2014爱思唯尔有限公司版权所有。
This paper reports novel MEMS and NEMS-based fabrication processes for biocompatible, hollow cylindrical ferromagnetic structures for potential use as contrast agents for magnetic resonance imaging (MRI). Compared to previous works on Ni-based cylindrical-nanoshells and Fe-based double-disk particles, bio-compatibility and yield issues were strongly considered in this development of a simplified fabrication process incorporating iron oxide thin films. The novel, simplified fabrication processes developed herein yield robust, reproducible fabrication methodologies for the further development of this new class of MRI contrast agents. Specifically, both micron- and nano-scale hollow cylindrical agents were successfully fabricated, the size regimes of which enable a wide array of potential imaging applications. The use of top-down engineering approaches to MRI contrast agent design such as reported herein offers the capacity for multiplexed imaging which may dramatically potentiate the capabilities of MRI imaging. (C) 2014 Elsevier B.V. All rights reserved.