Sleep duration and association with cardiometabolic health in adolescents and adults with type 1 diabetes: Results from the BCQR-T1D study.
Sleep duration and association with cardiometabolic health in adolescents and adults with type 1 diabetes: Results from the BCQR-T1D study.
复制标题
患有 1 型糖尿病的青少年和成人的睡眠持续时间及其与心脏代谢健康的关系：BCQR-T1D 研究的结果。
DOI：
10.1111/dom.15582
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Nadeau,KristenJ
中科院分区：
文献类型：
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作者：
Simon,StaceyL;Snell-Bergeon,JanetK;Schäfer,Michal;Barker,AlexJ;Browne,LornaP;Truong,Uyen;Tell,ShoshanaS;Vigers,Timothy;Baumgartner,AmyD;Lyon,Ellen;Polsky,Sarit;Schauer,IreneE;Nadeau,KristenJ
目的1型糖尿病（T1 D）增加了心血管疾病的发病率和死亡率，睡眠不足是普遍现象。新出现的证据表明睡眠与心脏代谢健康之间存在联系，但这尚未在T1 D患者的整个生命周期中进行检查。我们的目的是在对一项为期4周的双盲、随机顺序、溴隐亭快速释放（BCQR）治疗的安慰剂对照交叉试验，在条件之间具有4周的洗脱期。（19 - 60岁）和42名青少年（12 - 18岁）T1 D>9个月的患者完成了1周的家庭监测，使用腕戴式体动仪估计睡眠时间，并进行了连续血糖监测、人体测量、动脉硬度、磁共振成像结果62%的青少年和74%的成年人在基线时每晚睡眠<7小时。校正年龄、性别和糖尿病病程后，基线睡眠<7小时/晚与较高的体重指数、较高的腰围、较高的收缩压、较差的动脉僵硬度和较低的估计胰岛素敏感性相关（allp<0.05）。当按年龄组进行检查时，睡眠时间与心脏代谢健康结果之间的关联仍然显着，主要是青少年。在青少年中，清醒时间显着较晚（p= 0.027），在床上的时间显着较长的BCQR与安慰剂（p= 0.049）conclusionsObjective-measured睡眠<7小时每晚是普遍的青少年和成人T1 D和较差的心脏代谢健康标志物。仅在青少年中观察到BCQR治疗后睡眠的微小变化。睡眠可能是改善T1 D患者心脏代谢健康的一个重要而新颖的目标。
AimType 1 diabetes (T1D) increases the risk of morbidity and mortality from cardiovascular disease, and insufficient sleep is prevalent. Emerging evidence suggests a link between sleep and cardiometabolic health, but this has not been examined across the lifespan in individuals with T1D. We aimed to examine associations between sleep and cardiometabolic health in adolescents and adults with T1D in a secondary analysis of data from a 4‐week double‐blind, random‐order, placebo‐controlled crossover trial of bromocriptine quick release (BCQR) therapy with a 4‐week washout in between conditions.Materials and MethodsForty‐two adults (19‐60 years) and 42 adolescents (12‐18 years) with T1D >9 months completed 1 week of home monitoring with wrist‐worn actigraphy to estimate sleep duration and continuous glucose monitoring, anthropometrics, arterial stiffness, magnetic resonance imaging (adolescents only), and fasting laboratory testing at each treatment phase.ResultsSixty‐two per cent of adolescents and 74% of adults obtained <7 h of sleep per night at baseline. After adjustment for age, sex and diabetes duration, baseline sleep <7 h per night was associated with a higher body mass index, a higher waist circumference, a higher systolic blood pressure, worse arterial stiffness and a lower estimated insulin sensitivity (allp< .05). When examined by age group, associations between sleep duration and cardiometabolic health outcomes remained significant, predominantly for adolescents. In adolescents only, wake time was significantly later (p= .027) and time in bed was significantly longer with BCQR versus placebo (p= .049).ConclusionsObjectively measured sleep <7 h per night was prevalent in adolescents and adults with T1D and associated with poorer cardiometabolic health markers. Small changes in sleep were seen following BCQR treatment in adolescents only. Sleep may be an important and novel target for improving cardiometabolic health in individuals with T1D.