The MRL Mouse: A Model of Regeneration and Cancer
The MRL Mouse: A Model of Regeneration and Cancer
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DOI：
10.1007/978-3-319-16733-6_3
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发表时间：
2015-01-01
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影响因子：
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通讯作者：
Naviaux, Robert K.
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文献类型：
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作者：
Heber-Katz, Ellen;Naviaux, Robert K.
再生和癌症的交叉点一直被假设是由于愈合能力和癌症倾向之间的良好建立的反比关系。MRL小鼠，一种再生的哺乳动物模型，提供了一个机会，实验探索这一假设。我们提供了与代谢、炎症、遗传学和饮食有关的数据，这些数据不仅支持这一假设，而且提供了将这些促癌特征联系起来的机制性见解。特别是，这种小鼠具有肿瘤微环境的许多要素，例如促炎反应，高脂饮食（HFD）下增强的再生愈合，支持肿瘤生长的环境，基础代谢与有氧糖酵解的使用使人联想到瓦尔堡效应，尽管它允许肿瘤移植，但它对癌症诱导具有抗性。对促炎性HFD的作用和再生能力的遗传研究提供了解剖这些关系的链接。
The intersection of regeneration and cancer has long been hypothesized to be due to the well-established inverse relationship between the capacity to heal and the propensity for cancer.The MRL mouse, a mammalian model of regeneration, provides an opportunity to experimentally explore this hypothesis. We present data relating to metabolism, inflammation, genetics, and diet, which not only support the hypothesis but also provide mechanistic insight linking these pro-carcinogenic traits.In particular, this mouse has many elements of the tumor microenvironment such as a pro-inflammatory response, enhanced regenerative healing under a high-fat diet (HFD), an environment supportive of tumor growth, the use of a basal metabolism with aerobic glycolysis reminiscent of the Warburg effect, and although it is permissive for tumor transplantation, it is resistant to cancer induction. Genetic studies on the role of pro-inflammatory HFDs and regenerative capacity provide links to dissecting these relationships.