Using normalized EMG to define the nociceptive flexion reflex (NFR) threshold: Further evaluation of standardized NFR scoring criteria
Using normalized EMG to define the nociceptive flexion reflex (NFR) threshold: Further evaluation of standardized NFR scoring criteria
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DOI：
10.1016/j.pain.2009.06.022
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发表时间：
2009-09-01
期刊：
影响因子：
7.4
通讯作者：
McGlone, Sarah
中科院分区：
文献类型：
--
作者：
France, Christopher R.;Rhudy, Jamie L.;McGlone, Sarah
在许多临床和实验研究中，伤害性屈曲反射（NFR）已被用作研究脊髓伤害性过程的心理生理学工具。尽管NFR被广泛使用。很少有人尝试经验性地测试和比较不同的评分标准以检测反射的存在/不存在。本研究就是为了解决这一问题而进行的。研究1（N = 56名健康参与者）检查了先前报告中检查的15种不同评分标准的可靠性。研究2（N = 73名健康受试者）通过检查基于股二头肌活动的标准化评分标准扩展了这项工作，该标准与伤害性刺激无关（参考收缩，最大收缩）。在这两项研究中，受试者操作特征（ROC）分析用于评估和比较不同的评分方法。结果表明，基于ROC曲线下面积及其统计学显著性，许多不同的标准可用于定义NFR阈值;然而，NFR间期z评分[（NFR间期平均值-基线平均值）/基线SD]成为具有最高准确度的评分标准，并且具有跨样本可靠的临界点。这些发现支持应用一个共同的NFR评分标准，以加强不同研究实验室和研究样本之间的结果的直接比较。(C)2009年国际疼痛研究协会。Elsevier B. V.出版，保留所有权利。
The nociceptive flexion reflex (NFR) has been used as a psychophysiological tool to Study spinal nociceptive processes in numerous clinical and experimental Studies. Despite widespread use of the NFR. few attempts have been made to empirically test and compare different scoring criteria to detect the presence/absence of the reflex. The present studies were conducted to address this issue. Study 1 (N = 56 healthy participants) examined the reliability of 15 different scoring Criteria that were examined in a previous report. Study 2 (N = 73 healthy participants) extended this work by examining normalized scoring criteria based on biceps femoris activity unrelated to noxious stimulation (reference contraction, maximal contraction). In both studies, receiver operating characteristics (ROCs) analyses were used to evaluate and compare different scoring methods. The results indicate that a number of different criteria were acceptable for defining an NFR threshold based on the area under the ROC curve and its statistical significance; however, NFR Interval z score [(NFR Interval Mean - baseline mean)/baseline SD] emerged as the scoring criterion with the greatest accuracy and With cut-points that are reliable across samples. These findings support the application of a common NFR scoring criterion to enhance direct comparison of results across different research laboratories and study samples. (C) 2009 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.