The Medical Treatment of Peptic Ulcer
The Medical Treatment of Peptic Ulcer
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消化性溃疡的药物治疗
DOI：
10.1136/bmj.1.3914.69
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发表时间：
1936
影响因子：
--
通讯作者：
Bennett Ti
中科院分区：
文献类型：
--
作者：
Bennett Ti
第一部分消化性溃疡的药物治疗必须持续很长时间。如果考虑到小腿硬结性溃疡永久愈合所需的时间，很明显，位于活动部位（如胃壁或十二指肠壁）的慢性溃疡，并经常受到活性消化酶的侵蚀，一定是一种难以牢固永久愈合的病变。当我们还记得消化性溃疡经常是存在的，而且是活动的，根本不引起任何症状，特别是，几天的严格治疗有时会消除所有的症状时，我们就会意识到，永久的愈合需要病人和医生在很长一段时间内的合作，在此期间，疼痛和不适都不会提醒病人必须小心。如果只有胃溃疡和十二指肠溃疡在完全愈合之前仍然疼痛或不舒服，那么复发率就会比现在少得多。事实上，可以说，消化性溃疡的药物治疗，如果在足够的时间内适当地应用，除了一小部分病例外，在所有病例中都是非常令人满意的。消化性溃疡的新的医学治疗方法不时出现，最后两种备受关注的是粘蛋白治疗和组氨酸治疗。然而，在这篇文章中，我将讨论传统的医疗方法，在过去的20年里，在许多国家的许多医生手中，这些方法在很大程度上取得了很好的效果。
PART I The medical treatment of peptic-ulcer must needs be long. If the time necessary to secure the permanent healing of a callous ulcer of the leg is considered, it is obvious that a chronic ulcer placed in an actively movinig part such as the wall of the stomach or duodenum, and frequently bathedby active digestive ferments, must be a difficult lesion to heal firmly and permanently. When it is also remembered that a peptic ulcer is often present and active without causing any symptoms at all--and, particularly, that a few days ofstrict treatment will Sometimes remove all symptoms-it will be realized that permanent healing requires the collaboratipn of patient knd doctor during a long period, during which neither pain nor discomfort may remind the patient of the necessity for being careful. If only ulcers of the stomach and duodenum remained painful or uncomfortable until they were properly healed, there would be far fewer relapses than occur at present. As it is, it may be said that the medical treatment of peptic ulcer, properly applied over a sufficient period, is extremely satisfactory in all but a small percentage of cases. From time to time new medical treatments for peptic ulcer appear, the last two to have received much attention being the mucin treatment and the histidine treatment. In this article, however, I will deal with the orthodox lines of medical treatment, which in the hands of many physicians in many countries have yielded excellent results in a high proportion of cases during the last twenty years.