Investigation of association between hip morphology and prevalence of osteoarthritis.
Investigation of association between hip morphology and prevalence of osteoarthritis.
复制标题
髋关节形态与骨关节炎患病率关系的调查
DOI：
10.1038/srep23477
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发表时间：
2016-03-22
影响因子：
4.6
通讯作者：
Yang L
中科院分区：
文献类型：
--
作者：
Zeng WN;Wang FY;Chen C;Zhang Y;Gong XY;Zhou K;Chen Z;Wang D;Zhou ZK;Yang L
髋骨关节炎（OA）的病因尚不清楚，髋关节形态异常被认为是髋骨关节炎的一个促成因素。假设正常人和 OA 受试者之间的髋部存在细微的解剖形态差异；本研究的目的是基于 CT 3D 重建来探讨这些容易导致髋关节 OA 的解剖学差异。本研究招募了 93 名正常受试者（186 髋）和 66 名轻至中度髋关节 OA 受试者（132 髋）。评估头颈关系的三个参数：平移、旋转和凹度。平移是股骨头相对于颈轴的潜在平移运动。以骺痕描述旋转，评价头颈交界处股骨头相对于颈部的旋转倾向。凹度用于评估头部与颈部连接处的球形度。还测量了股骨颈前倾角和髋臼的一些参数：前倾角、倾斜度和CE角。通过比较发现，OA受试者的股骨头球形度、头颈交界处凹度、髋臼及股骨颈前倾角均较低；但髋臼覆盖范围更大。这些特征增加了 OA 受试者患髋关节 OA 的风险。
The cause of hip osteoarthritis (OA) remains unclear, morphologic abnormality of hip was thought to be a contributing factor to hip OA. The hypothesis was that there were subtle anatomical morphology differences of the hip between normal and OA subjects; the objective of this study was to explore these anatomical differences which are predisposing to hip OA based on CT 3D reconstruction. Ninety-three normal subjects (186 hips) and 66 mild-to-moderate hip OA subjects (132 hips) were recruited in this study. Three parameters of the head-neck relationship were assessed: translation, rotation and concavity. Translation was the potential translational movements of femoral head related to the neck’s axis. Rotation was described by the physeal scar to evaluate the rotation tendency of femoral head related to the neck at the head-neck junction. Concavity was used to assess the sphericity of the head as it joins the neck. The femoral neck anteversion angle and some parameters of the acetabulum: anteversion, inclination and CE angle were measured too. By comparison, it was found that OA subjects had less femoral head sphericity, head-neck junction concavity, acetabular and femoral neck anteversion angle; but greater acetabular coverage. These characteristics increased the risk of hip OA in OA subjects.