Fixation pattern and macular sensitivity in eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration. A microperimetry study.
Fixation pattern and macular sensitivity in eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration. A microperimetry study.
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DOI：
10.1080/08820530490882896
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发表时间：
2004-03-01
影响因子：
1.7
通讯作者：
Varano, Monica
中科院分区：
文献类型：
--
作者：
Midena, Edoardo;Radin, Pietro Paolo;Varano, Monica
目的：探讨年龄相关性黄斑变性（AMD）继发的中央凹下脉络膜新生血管（CNV）对黄斑功能参数的影响。方法：对98例继发于AMD的中央凹下CNV患者118只眼进行评价。进行最佳矫正视力（ETDRS）、眼底摄影和荧光素血管造影。显微视力（眼底相关视力）用于量化黄斑敏感性和固定模式（位置和稳定性）。结果：118只眼中，中心固定26只（21.9%），中心不良18只（15.1%），偏心固定74只（63.0%）；稳定31例（26.0%），相对不稳定42例（35.6%），不稳定45例（38.4%）。75眼（63.4%）发现密集的中心暗斑。中央凹下CNV的血管造影分类（隐匿性vs典型性）与固定方式（定位：P = 0.274；稳定性：P = 0.385）和致密暗斑的存在（P = 0.41）无显著相关性。结论：AMD继发于中央凹下CNV的黄斑敏感性和固定模式的显微测量为这些眼睛的视力损害影响提供了新的数据。此外，显微视野检查改善了AMD患者中央凹下CNV的功能评估。
PURPOSE: To investigate the effects of subfoveal choroidal neovascularizzation (CNV) secondary to age-related macular degeneration (AMD) on macular functional parameters quantified with an automatic fundus perimeter.METHODS: 118 eyes of 98 consecutive patients with subfoveal CNV secondary to AMD were evaluated. Best corrected visual acuity (ETDRS charts), fundus photography, and fluorescein angiography were performed. Microperimetry (fundus-related perimetry) was used to quantify macular sensitivity and fixation pattern (location and stability).RESULTS: Of 118 eyes: 26 (21.9%) had central, 18 (15.1%) poor central and 74 (63.0%) eccentric fixation; 31 (26.0%) had stable, 42 (35.6%) relatively unstable and 45 (38.4%) unstable fixation. In 75 eyes (63.4%) a dense central scotoma was found. Angiographic classification of subfoveal CNV (occult versus classic) was not significantly related to fixation pattern (location: P = 0.274; stability: P = 0.385), and presence of dense scotoma (P = 0.41).CONCLUSION: Microperimetric quantification of macular sensitivity and fixation pattern in eyes with subfoveal CNV secondary to AMD offers new data about the impact of visual impairment in these eyes. Moreover, microperimetry improves the functional evaluation of subfoveal CNV in AMD.