Automated synthesis of [11C]choline, a positron-emitting tracer for tumor imaging
Automated synthesis of [11C]choline, a positron-emitting tracer for tumor imaging
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DOI：
10.1016/s0969-8043(98)00097-9
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发表时间：
1999-03-01
影响因子：
1.6
通讯作者：
Yuasa, M
中科院分区：
文献类型：
--
作者：
Hara, T;Yuasa, M
（β-羟乙基）三（[C-11]甲基）铵（[C-11]胆碱）是一种在使用正电子发射断层扫描（PET）成像各种人类肿瘤中非常有效的示踪剂。我们建立了一台计算机控制的[C-11]胆碱合成装置，实现了全过程的自动化合成和产品提纯。设置简单，过程快速。在20分钟内，可从26 GBq [C-11]CO2中获得11 GBq [C-11]胆碱（氯化物）。最终产品是无菌和无热原的[C-11]胆碱“注射液”。(C)1999爱思唯尔科技有限公司。保留所有权利。
(beta-Hydroxyethyl)tri([C-11]methyl)ammonium ([C-11]choline) is a tracer very effective in imaging various human tumors using positron emission tomography (PET). We have constructed a computer-controlled [C-11]choline synthetic apparatus which carries out the whole process of synthesis and product purification automatically. The setup is simple and the process quick. In 20 min, 11 GBq of [C-11]choline (chloride) is obtainable from 26 GBq of [C-11]CO2. The final product is a sterile and pyrogen-free [C-11]choline "injection". (C) 1999 Elsevier Science Ltd. All rights reserved.