Early patterns of symptom change signal remission with interpersonal psychotherapy for depressed adolescents.
Early patterns of symptom change signal remission with interpersonal psychotherapy for depressed adolescents.
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DOI：
10.1002/da.20849
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发表时间：
2011-07
影响因子：
7.4
通讯作者：
Mufson, Laura
中科院分区：
文献类型：
--
作者：
Gunlicks-Stoessel, Meredith;Mufson, Laura
本研究考察了在治疗过程中不同时间点抑郁症状的减轻是否预示着在学校卫生诊所接受人际心理治疗（IPT-A）或常规治疗（TAU）治疗的抑郁青少年的缓解。参与者是63名青少年（12-18岁），他们来自一项随机对照临床试验，研究了IPT-A的有效性。青少年随机接受由学校心理健康临床医生提供的IPT-A或TAU。评估在基线和第4、8、12和16周（或早期终止）完成，包括汉密尔顿抑郁评定量表（HRSD）。使用受试者工作特征分析来确定试验结束（第16周）时HRSD降低的最佳时间点和程度（HRSD < 7）。第4周是将青少年分为可能缓解或不可能缓解IPT-A和TAU的最佳时间点。HRSD较基线降低16.2%代表了预测青少年IPT-A治疗第16周缓解状态的最佳综合敏感性和特异性。抑郁症状减少24.4%是预测TAU缓解状态的最佳综合敏感性和特异性。这些发现为IPT-A缓解的一个早期标志提供了初步证据。更大样本的复制表明，在4周的IPT-A治疗后，抑郁青少年的抑郁症状没有至少减少16.2%，可能会从治疗计划的改变中受益。
This study examined whether reductions in depression symptoms at different time points over the course of therapy predict remission for depressed adolescents treated with interpersonal psychotherapy (IPT-A) or treatment as usual (TAU) delivered in school-based health clinics. Participants were 63 adolescents (ages 12–18) drawn from a randomized controlled clinical trial examining the effectiveness of IPT-A. Adolescents were randomized to receive IPT-A or TAU delivered by school-based mental health clinicians. Assessments were completed at baseline and weeks 4, 8, 12, and 16 (or at early termination) and included the Hamilton Rating Scale for Depression (HRSD). Receiver operating characteristic analysis was used to identify the time point and degree of reduction in HRSD that best predicted remission (HRSD < 7) at the end of the trial (week 16). Week 4 was the best time point for classifying adolescents as likely to remit or not likely to remit for both IPT-A and TAU. A 16.2% reduction in HRSD from baseline represented the best combined sensitivity and specificity in predicting week 16 remission status for adolescents treated with IPT-A. A 24.4% reduction in depressive symptoms represented the best combined sensitivity and specificity in predicting remission status for TAU. These findings provide preliminary evidence of one early marker of remission with IPT-A. Replication with larger samples would suggest that depressed adolescents who have not demonstrated at least a 16.2% reduction in their depressive symptoms after 4 weeks of IPT-A may benefit from a change in the treatment plan.
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影响因子：
4.9
作者：
Kuhl, J;Jarkon-Horlick, L;Morrissey, RF
通讯作者：
Morrissey, RF
DOI：
10.1097/01.chi.0000233157.21925.71
发表时间：
2006-10-01
影响因子：
13.3
作者：
Melvin, Glenn A.;Tonge, Bruce J.;Klimkeit, Ester
通讯作者：
Klimkeit, Ester
DOI：
10.1097/01.chi.0000240838.78984.e2
发表时间：
2006-12-01
影响因子：
13.3
作者：
Curry, John;Rohde, Paul;March, John
通讯作者：
March, John
DOI：
10.1097/chi.0b013e3181977476
发表时间：
2009-03-01
影响因子：
13.3
作者：
Asarnow, Joan Rosenbaum;Emslie, Graham;Brent, David
通讯作者：
Brent, David
影响因子：
--
作者：
Mufson, L;Dorta, KP;Weissman, MM
通讯作者：
Weissman, MM