Linac-based intensity modulated total marrow irradiation (IM-TMI)
Linac-based intensity modulated total marrow irradiation (IM-TMI)
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DOI：
10.1177/153303460600500508
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发表时间：
2006-10-01
影响因子：
2.8
通讯作者：
Roeske, John C.
中科院分区：
文献类型：
--
作者：
Aydogan, Bulent;Mundt, Arno J.;Roeske, John C.
全身照射（TBI）已被用作治疗血液系统恶性肿瘤的全身治疗形式，并作为骨髓移植前的预处理方案。然而，标准技术与急性和慢性毒性有关，因为照射的正常组织体积很大。调强放射治疗（IMRT）能够使高剂量区域符合目标的形状，提供了一种减少放射相关后遗症的方法，并可能允许递送高于常规剂量的剂量。本研究的目的是调查的可行性直线加速器为基础的方法来调强全骨髓照射（IM-TMI），并讨论与其临床实施的挑战。基于直线加速器的IM-TMI的成功开发将代表放射治疗领域的进步，并可能降低与当前TBI技术相关的并发症的发生率和严重程度。
Total body irradiation (TBI) has been used as a form of systemic therapy for the treatment of hematological malignancies and as a pre-conditioning regimen prior to bone marrow transplant. However, standard techniques are associated with both acute and chronic toxicities due to the large volumes of normal tissue irradiated. Intensity modulated radiation therapy (IMRT), with its ability to conform the high dose region to the shape of the target, offers a method to reduce radiation related sequelae and potentially allow for the delivery of higher than conventional doses. The goal of this study is to investigate the feasibility of a linac-based approach to intensity modulated total marrow irradiation (IM-TMI) and to discuss the challenges associated with its clinical implementation. The successful development of linac-based IM-TMI would represent advancement in the field of radiotherapy and potentially reduce the incidence and severity of complications associated with current TBI techniques.