Myocardial homing and neovascularization by human bone marrow angioblasts is regulated by IL-8/Gro CXC chemokines
Myocardial homing and neovascularization by human bone marrow angioblasts is regulated by IL-8/Gro CXC chemokines
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DOI：
10.1016/j.yjmcc.2005.11.013
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发表时间：
2006-04-01
影响因子：
5
通讯作者：
Itescu, S
中科院分区：
文献类型：
--
作者：
Kocher, AA;Schuster, MD;Itescu, S
在成人中，新血管的形成既可以通过预先存在的成熟内皮细胞的血管生成，也可以通过骨髓来源的内皮前体介导的血管生成。我们最近在成人骨髓中分离出内皮祖细胞或成血管细胞，这些细胞对缺血组织（包括心肌）具有选择性迁移特性，可以归根并诱导血管生成。在这里，我们发现急性缺血后心肌产生IL-8/ gro - α CXC趋化因子家族显著增加，这为骨髓来源的内皮祖细胞或成血管细胞提供了趋化梯度。这种趋化因子介导的骨髓成血管细胞向缺血心脏的归巢调节了它们诱导心肌新生、防止心肌细胞凋亡和心脏功能恢复的能力。综上所述，我们的研究结果表明，CXC趋化因子在成人血管生成的调节中起着核心作用，并表明在自体人骨髓源性成血管细胞上调节趋化因子及其受体之间的相互作用可以增强缺血心肌组织的新生血管。(c) 2006 Elsevier Ltd.版权所有。
In the adult, new blood vessel formation can occur either through angiogenesis from pre-existing mature endothelium or vasculogenesis mediated by bone marrow-derived endothelial precursors. We recently isolated endothelial progenitor cells, or angioblasts, in human adult bone marrow which have selective migratory properties for ischemic tissues, including myocardium, to where they home and induce vasculogenesis. Here we show that myocardial production of the IL-8/Gro-alpha CXC chemokine family is significantly increased after acute ischemia, and that this provides a chemoattractant gradient for bone marrow-derived endothelial progenitors, or angioblasts. This chemokine-mediated homing of bone marrow angioblasts to the ischemic heart regulates their ability to induce myocardial neovascularization, protection against cardiomyocyte apoptosis, and functional cardiac recovery. Together, our results indicate that CXC chemokines play a central role in regulating vasculogenesis in the adult, and suggest that manipulation of interactions between chemokines and their receptors on autologous human bone marrow-derived angioblasts could augment neovascularization of ischemic myocardial tissue. (c) 2006 Elsevier Ltd. All rights reserved.