Contrast Material for Abdominal Dynamic Contrast-Enhanced 3D MR Angiography With Parallel Imaging: Intraindividual Equimolar Comparison of a Macrocyclic 1.0 M Gadolinium Chelate and a Linear Ionic 0.5 M Gadolinium Chelate
Contrast Material for Abdominal Dynamic Contrast-Enhanced 3D MR Angiography With Parallel Imaging: Intraindividual Equimolar Comparison of a Macrocyclic 1.0 M Gadolinium Chelate and a Linear Ionic 0.5 M Gadolinium Chelate
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DOI：
10.2214/ajr.09.3306
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发表时间：
2010-03-01
影响因子：
5
通讯作者：
Willinek, Winfried Albert
中科院分区：
文献类型：
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作者：
Hadizadeh, Dariusch Reza;Von Falkenhausen, Marcus;Willinek, Winfried Albert
OBJECTIVE.本研究的目的是比较大环1.0 M造影剂与线性离子0.5 M造影剂在等摩尔剂量方面的图像质量和数量的血管节段可视化腹部动态对比增强3D MR angiography.Subjects和方法。在一项个体内比较研究中，15名患者（6名女性，9名男性;平均年龄，53 +/- 12.1岁;范围，25-72岁）接受了32次使用并行成像技术进行的1.5 T全身对比增强3D MR血管造影检查。在随机和单独的会议，每例患者进行了检查后，静脉注射0.1 mmol/kg体重1.0 M大环钆布醇和0.5 M线性离子钆喷酸葡胺。在动脉、门静脉和静脉阶段使用相同的成像协议采集三维数据集。定量分析包括与邻近背景组织相比的血管的对比度测量（Student t检验）。定性分析由两名放射科医生独立进行，涉及动脉和静脉血管段的可视化和整体图像质量（Wilcoxon检验）。与0.5 M线性离子型钆喷酸葡胺相比，1.0 M大环钆布醇给药后单个血管节段的可视化明显更好（p < 0.001）。1.0 M大环钆布醇的总体图像质量上级，但差异不显著。注射1.0 M大环钆布醇后，血管与背景对比度显著升高（动脉期，0.90，p = 0.02;门静脉期，0.78，p = 0.0002;静脉期，0.74，p = 0.0002）与0.5 M线性离子型钆喷酸葡胺相比（动脉期0.89，门静脉期0.73，静脉期0.67）。在腹部对比增强三维磁共振血管造影术，描绘腹部小血管是显着更好，血管组织对比显着高于1.0 M大环钆布醇比等摩尔剂量的0.5 M线性离子钆喷酸葡胺。
OBJECTIVE. The purpose of this study was to compare a macrocyclic 1.0 M contrast agent with a linear ionic 0.5 M contrast agent at equimolar dosage in regard to image quality and number of vessel segments visualized at abdominal dynamic contrast-enhanced 3D MR angiography.SUBJECTS AND METHODS. In an intraindividual comparative study, 15 patients (six women, nine men; mean age, 53 +/- 12.1 years; range, 25-72 years) underwent 32 1.5-T whole-body contrast-enhanced 3D MR angiographic examinations performed with parallel imaging technique. At random and in separate sessions, each patient was examined after IV injection of 0.1 mmol/kg body weight 1.0 M macrocyclic gadobutrol and 0.5 M linear ionic gadopentetate dimeglumine. Three-dimensional data sets were acquired in the arterial, portal venous, and venous phases with identical imaging protocols. Quantitative analysis included contrast measurements of vessels compared with adjacent background tissue (Student's t test). Qualitative analysis was performed independently by two radiologists with regard to visualization of arterial and venous vessel segments and overall image quality (Wilcoxon's test).RESULTS. Visualization of individual vessel segments was rated significantly better after administration of 1.0 M macrocyclic gadobutrol compared with 0.5 M linear ionic gadopentetate dimeglumine (p < 0.001). Overall image quality was superior with 1.0 M macrocyclic gadobutrol, but the difference was not significant. Vessel-to-background contrast after injection of 1.0 M macrocyclic gadobutrol was significantly higher (arterial phase, 0.90, p = 0.02; portal venous phase, 0.78, p = 0.0002; venous phase, 0.74, p = 0.0002) compared with 0.5 M linear ionic gadopentetate dimeglumine (arterial phase, 0.89; portal venous phase, 0.73; venous phase, 0.67).CONCLUSION. At abdominal contrast-enhanced 3D MR angiography, depiction of small abdominal vessels was significantly better and vessel-to-tissue contrast significantly higher with 1.0 M macrocyclic gadobutrol than with an equimolar dose of 0.5 M linear ionic gadopentetate dimeglumine.