Illuminating the center: Mechanisms regulating lumen formation and maintenance in mammary morphogenesis
Illuminating the center: Mechanisms regulating lumen formation and maintenance in mammary morphogenesis
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DOI：
10.1007/s10911-006-9030-4
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发表时间：
2006-10-01
影响因子：
2.5
通讯作者：
Muthuswamy, Senthil K.
中科院分区：
文献类型：
--
作者：
Reginato, Mauricio J.;Muthuswamy, Senthil K.
导管结构中存在的管腔需要用于传输流体和空气。对模型生物和培养细胞的研究表明，管腔可以通过多种机制产生，包括中心细胞的凋亡和上皮细胞的重塑。多项研究指出细胞凋亡在乳腺导管管腔形成过程中的作用。然而，其他机制在乳腺导管管腔形成过程中的作用很大程度上尚未被探索。了解管腔如何形成并保持不含细胞具有临床重要性，因为管腔空间的填充与癌症和炎症有关。因此，进一步的研究可以带来新的诊断和治疗机会。
The lumens present in ductal structures are required for transport of fluids and air. Studies in model organisms and cells in culture suggest that lumens can be generated by multiple mechanisms including apoptosis of centrally located cells, and re-modeling of epithelia. Several studies point to a role for apoptosis during lumen formation in the mammary ducts. However, a role for other mechanisms during lumen formation in the mammary ducts is largely unexplored. Understanding how lumens are formed and maintained free of cells is of clinical importance because filling of the luminal space is associated with cancer and inflammation. Thus, further investigation can lead to new diagnostic and therapeutic opportunities.