Correlation among geometric, densitometric, and mechanical properties in mandible and femur of osteoporotic rats
Correlation among geometric, densitometric, and mechanical properties in mandible and femur of osteoporotic rats
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DOI：
10.1007/s00774-007-0811-7
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发表时间：
2008-03-01
影响因子：
3.3
通讯作者：
Fujii, Akira
中科院分区：
文献类型：
--
作者：
Jiang, Gui-Zhen;Matsumoto, Hiroko;Fujii, Akira
我们以前已经证明了实验性骨质疏松大鼠的下颌骨和股骨的骨丢失及其预防药物，使用外周定量计算机断层扫描（pQCT）。在本研究中，下颌骨和股骨的力学性能和相关性，其几何和密度特性进行了研究，在卵巢切除大鼠有或无依替膦酸盐治疗。选用26周龄SPF级Wistar雌性大鼠54只，随机分为4组：（1）基础组（2）假手术组（Sham group）（3）去卵巢组（OVX组）（4）治疗组（OVX +依替膦酸盐，15只，0.1%Ca饲料）。通过pQCT测量下颌骨和股骨的总骨矿物质密度（BMD）、皮质BMD、横截面皮质骨面积、横截面皮质骨厚度、横截面惯性矩（CSMI）和极性强度指数（SSI）。用三点弯曲法测定下颌骨和股骨的破坏载荷。与基础组相比，Sham组两种骨的失效载荷显著较低。与Sham组相比，OVX组下颌骨和股骨的失效载荷分别降低了8%和7%。与OVX组相比，依替膦酸盐治疗导致失败负荷增加。失效载荷与pQCT评估的变量相关，尤其是与皮质骨面积和总BMD相关。此外，下颌骨的几何和密度特性和失效载荷与股骨的几何和密度特性和失效载荷具有相关性。
We have previously demonstrated bone loss of the mandible and femur in experimental osteoporotic rats and its prevention by medication, using peripheral quantitative computed tomography (pQCT). In the present study, the mechanical properties of the mandible and femur and the correlation to their geometric and densitometric properties were studied in ovariectomized rats with or without etidronate treatment. Fifty-four Wistar strain SPF female rats, 26 weeks old, were randomly assigned to four groups: (1) Basal group (12 rats, 1.0% Ca diet); (2) Sham group (Sham-operated, 12 rats, 0.1% Ca diet); (3) OVX group (ovariectomized, 15 rats, 0.1% Ca diet); (4) Treated group (OVX + etidronate, 15 rats, 0.1% Ca diet). Total bone mineral density (BMD), cortical BMD, cross-sectional cortical bone area, cross-sectional cortical bone thickness, crosssectional moment of inertia (CSMI), and polar strength index (SSI) of the mandible and femur were measured by pQCT. The failure load of mandible and femur was evaluated by three-point bending. The failure load of both bones was significantly lower in the Sham group compared with the Basal group. The OVX group further had a 8% and 7% decrease in the failure load for mandible and femur, respectively, compared to the Sham group. Treatment with etidronate led to an increase in the failure load compared with the OVX group. The failure load was related to the pQCT-assessed variables, especially with cortical bone area and total BMD. Moreover, the geometric and densitometric properties and failure load in the mandible showed a correlation to those in the femur.