Platelet derived growth factor regulates ABCA1 expression in vascular smooth muscle cells
Platelet derived growth factor regulates ABCA1 expression in vascular smooth muscle cells
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DOI：
10.1016/j.febslet.2006.07.001
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发表时间：
2006-08-07
期刊：
影响因子：
3.5
通讯作者：
Ishida, Toshihiko
中科院分区：
文献类型：
--
作者：
Nagao, Sachi;Murao, Koji;Ishida, Toshihiko
三磷酸腺苷结合盒转运体A1(ABCA1)调节外周细胞向高密度脂蛋白的脂质外流。血小板衍生生长因子(PDGF)是一种强有力的有丝分裂原，能使血管平滑肌细胞参与动脉粥样硬化。在这篇报道中，我们发现PDGF抑制了培养的血管平滑肌细胞中ABCA1的内源性表达。将CRL-208细胞暴露于PDGF可引起PI3K，Akt下游的一种蛋白的快速磷酸化。PI3-K亚基p110和Akt的结构活性形式都抑制了ABCA1启动子的活性。总之，PI3-K-Akt通路参与了PDGF抑制ABCA1表达的过程。(C)2006年欧洲生化学会联合会。爱思唯尔出版，版权所有。
The ATP-binding cassette transporter A1 (ABCA1) regulates lipid efflux from peripheral cells to High-density lipoprotein. The platelet-derived growth factor (PDGF) is a potent mitogen that enables vascular smooth muscle cells to participate in atherosclerosis. In this report, we showed that PDGF suppressed endogenous expression of ABCA1 in cultured vascular smooth muscle cells. Exposure of CRL-208 cells to PDGF elicited a rapid phosphorylation of a kinase downstream from PI3K, Akt. The constitutively active form of both p110, a subunit of PI3-K, and Akt inhibited activity of the ABCA1 promoter. In conclusion, PI3-K-Akt pathways participate in PDGF-suppression of ABCA1 expression. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.