PROTOCHORDATE ALLORECOGNITION IS CONTROLLED BY A MHC-LIKE GENE SYSTEM
PROTOCHORDATE ALLORECOGNITION IS CONTROLLED BY A MHC-LIKE GENE SYSTEM
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DOI：
10.1038/295499a0
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发表时间：
1982-01-01
期刊：
影响因子：
64.8
通讯作者：
WEISSMAN, IL
中科院分区：
文献类型：
--
作者：
SCOFIELD, VL;SCHLUMPBERGER, JM;WEISSMAN, IL
与脊椎动物不同，殖民地被囊动物在自然界中经历移植。葡萄孢属菌落之间的排斥或接受是由一个具有多个等位基因的单基因位点控制的。相同的遗传区域显然通过阻止共享等位基因的配子之间的受精来保持这种多态性。Botryllus组织相容性系统可能反映了祖先MHC（主要组织相容性复合体）基因的原始适应功能。
Colonial tunicates, unlike vertebrates, undergo transplantation in nature. Rejection or acceptance between colonies of Botryllus is controlled by a single gene locus with multiple alleles. The same genetic region apparently maintains this polymorphism by preventing fertilization between gametes sharing alleles. The Botryllus histocompatibility system may reflect the original adaptive function of ancestral MHC [major histocompatibility complex] genes.