Exotic mitotic mechanisms.

Exotic mitotic mechanisms.
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DOI:
10.1098/rsob.120140
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发表时间:
2012-12-05
期刊:
影响因子:
5.8
通讯作者:
McAinsh AD
McAinsh AD
中科院分区:
生物学2区
文献类型:
--
作者:
Drechsler H;McAinsh AD

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大约20亿年前真核生物的出现对染色体分离机制提出了新的挑战:核膜将多个大而线性的染色体从微管组织中心物理分离。在这篇综述中,我们列出了真核细胞用来解决这个问题的各种解决方案,并展示了如何远离“主流”有丝分裂可以教会我们很多关于驱动染色体分离的机制和机制。我们讨论了膜、核孔和着丝点在有丝分裂过程中产生染色体分离所必需的力之间密切的功能和物理关系的证据。
The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope. In this review, we set out the diverse solutions that eukaryotic cells use to solve this problem, and show how stepping away from ‘mainstream’ mitosis can teach us much about the mechanisms and mechanics that can drive chromosome segregation. We discuss the evidence for a close functional and physical relationship between membranes, nuclear pores and kinetochores in generating the forces necessary for chromosome segregation during mitosis.
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