Hepatocyte growth factor as an enhancer of NMDA currents and synaptic plasticity in the hippocampus
Hepatocyte growth factor as an enhancer of NMDA currents and synaptic plasticity in the hippocampus
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DOI：
10.1016/j.neuroscience.2004.06.031
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发表时间：
2004-01-01
期刊：
影响因子：
3.3
通讯作者：
Matsuki, N
中科院分区：
文献类型：
--
作者：
Akimoto, M;Baba, A;Matsuki, N
肝细胞生长因子（HGF）促进未成熟神经元的存活和迁移，但其在成熟大脑中的作用仍然难以捉摸。在幼年大鼠的海马中，我们发现HGF受体c-Met在神经元中表达。此外，它是高度酪氨酸磷酸化的，比正常条件下肝脏中的磷酸化程度更高，这表明受体被激活，并且 HGF 可能在完整的大脑中持续发挥作用。外源性应用HGF增强了海马CA1区的突触长时程增强（LTP），但不影响长时程抑制。我们进一步发现 HGF 增强了切片和分离神经元中 N-甲基-D-天冬氨酸受体介导的电流。这种增强可能是 LTP 增强的基础。考虑到已知 HGF 和 c-Met 的表达都是由缺血刺激诱导的，这种调节将为与致病性缺血状态共享的神经元调节系统提供新的理解。 (C) 2004 年国际广播组织。由爱思唯尔有限公司出版。保留所有权利。
Hepatocyte growth factor (HGF) promotes the survival and migration of immature neurons, but its role in the mature brain has remained elusive. In the hippocampus of juvenile rats, we found that the HGF receptor c-Met was expressed in neurons. Furthermore, it was highly Tyr-phosphorylated, more so than in the liver under normal conditions, suggesting that the receptor is activated and that HGF may act continuously in the intact brain. Exogenously applied HGF enhanced synaptic long-term potentiation (LTP) in the CA1 region of hippocampus, but did not affect long-term depression. We further found that HGF augmented N-methyl-D-aspartate receptor-mediated currents in both slices and dissociated neurons. This augmentation is likely to underlie the enhancement of LTP. Considering that the expression of both HGF and c-Met are known to be induced by ischemic stimuli, this modulation would provide a novel understanding of a neuronal regulatory systems shared with pathogenic ischemic states. (C) 2004 IBRO. Published by Elsevier Ltd. All rights reserved.