Characteristics of eosinophilic and non-eosinophilic asthma during treatment with inhaled corticosteroids
Characteristics of eosinophilic and non-eosinophilic asthma during treatment with inhaled corticosteroids
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DOI：
10.3109/02770903.2014.975357
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发表时间：
2015-01-01
影响因子：
1.9
通讯作者：
Narita, Ichiei
中科院分区：
文献类型：
--
作者：
Furukawa, Toshiki;Sakagami, Takuro;Narita, Ichiei
Objective: Eosinophilic inflammation in the respiratory tract is a hallmark of bronchial asthma. In naive cases, the inflammatory profile is associated with disease severity and reactivity to inhaled corticosteroids (ICS). Sustained airway eosinophilia has been reported during ICS treatment. However, the immunological characteristics of these cases are not known and it is unclear if this situation contributes to asthma control. This study was performed to determine the answer of these questions. Methods: To compare phenotypes of eosinophilic and non-eosinophilic asthma (EA and NEA, respectively) under ICS treatment, clinical data were obtained from asthmatic subjects (n = 22) and healthy controls (n = 10), and the leukocyte compositions of induced sputum and peripheral blood were determined. T lymphocyte profiles in systemic blood were assessed by flow cytometry. Results: A higher frequency of emergency room visits was observed in the NEA group, which had a higher neutrophil count relative to the total inflammatory cell population in induced sputum than the EA group (59.5 versus 36.6%; p
