Approach to assessing determinants of glucose homeostasis in the conscious mouse.
Approach to assessing determinants of glucose homeostasis in the conscious mouse.
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DOI：
10.1007/s00335-014-9533-z
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发表时间：
2014-10
期刊：
影响因子：
2.5
通讯作者：
Lantier, Louise
中科院分区：
文献类型：
--
作者：
Hughey, Curtis C.;Wasserman, David H.;Lee-Young, Robert S.;Lantier, Louise
肥胖和2型糖尿病降低了患者的生活质量，并给医疗保健系统带来了相当大的负担。此外，预计这些疾病的有害影响将持续存在甚至恶化。糖尿病的特征是胰岛素作用和葡萄糖稳态受损。这导致基础科学中使用的代谢疾病小鼠模型数量迅速增加，以帮助更好地理解与肥胖和糖尿病相关的代谢失调，识别治疗靶点，并发现有效的治疗方法。本文简要介绍了最常用的代谢疾病模型。介绍了评估小鼠代谢表型的标准方法和技术，特别强调葡萄糖处理和能量平衡。本文还讨论了与研究设计、选择和执行葡萄糖代谢代谢试验、数据呈现和结果解释相关的问题。
Obesity and type 2 diabetes lessen the quality of life of those afflicted and place considerable burden on the healthcare system. Furthermore, the detrimental impact of these pathologies is expected to persist or even worsen. Diabetes is characterized by impaired insulin action and glucose homeostasis. This has led to a rapid increase in the number of mouse models of metabolic disease being used in the basic sciences to assist in facilitating a greater understanding of the metabolic dysregulation associated with obesity and diabetes, the identification of therapeutic targets, and the discovery of effective treatments. This review briefly describes the most frequently utilized models of metabolic disease. A presentation of standard methods and technologies on the horizon for assessing metabolic phenotypes in mice, with particular emphasis on glucose handling and energy balance, is provided. The article also addresses issues related to study design, selection and execution of metabolic tests of glucose metabolism, the presentation of data, and interpretation of results.
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在四种常用的近交小鼠菌株中的体内葡萄糖代谢。
影响因子：
7.7
作者：
Berglund, Eric D.;Li, Candice Y.;Poffenberger, Greg;Ayala, Julio E.;Fueger, Patrick T.;Willis, Shannon E.;Jewell, Marybeth M.;Powers, Alvin C.;Wasserman, David H.
通讯作者：
Wasserman, David H.
影响因子：
7.7
作者：
Butler AA;Kozak LP
通讯作者：
Kozak LP
影响因子：
7.7
作者：
Bonner JS;Lantier L;Hasenour CM;James FD;Bracy DP;Wasserman DH
通讯作者：
Wasserman DH
影响因子：
4.2
作者：
Chicco, A;D'Alessandro, ME;Lombardo, YB
通讯作者：
Lombardo, YB
影响因子：
16
作者：
Bruning, JC;Michael, MD;Kahn, CR
通讯作者：
Kahn, CR