Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis.
Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis.
复制标题
溶血双胞菌可抑制牙周病原菌牙龈卟啉单胞菌的生长。
DOI：
10.1111/pin.13110
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发表时间：
2021
影响因子：
4.6
通讯作者：
Yoshida A.
中科院分区：
文献类型：
--
作者：
Miyoshi T;Oge S;Nakata S;Ueno Y;Ukita H;Kousaka R;Miura Y;Yoshinari N;Yoshida A.
本研究旨在确定诱导治疗后切除的非小细胞肺癌中活肿瘤细胞百分比（%VTC）与肿瘤微环境之间的相关性。我们招募了72名非小细胞肺癌（NSCLC）患者，这些患者在手术前接受了化放疗（CRT）或化疗（CT）。计算活肿瘤细胞面积与总肿瘤面积的比率以获得%VTC。我们还通过免疫组织化学（IHC）检查了CD 4（+）、CD 8（+）、CD 20（+）和FOXP 3（+）肿瘤浸润淋巴细胞（TIL）、podoplanin（PDPN）（+）癌症相关成纤维细胞（CAF）和CD 204（+）肿瘤相关巨噬细胞（TAM）的数量。CRT组（n= 37）肿瘤的%VTC显著低于CT组（n= 35）（P< 0.001）。在CT组和CRT组中，%VTC均与CD 204（+）-TAM数量呈显著正相关（分别为P= 0.014和0.005）。仅在CRT组中，较高数量的CD 204（+）TAM与较短的总生存期（OS）（P= 0.007）和无复发生存期（RFS）（P= 0.015）相关。在CRT组中，CD 204（+）TAM的数量与%VTC和预后相关，表明这些细胞可能在CRT后特定微环境中对残留肺癌具有促肿瘤作用。
This study aims to determine the correlation between the percent viable tumor cells (%VTC) and the tumor microenvironment in resected non‐small cell lung cancer after induction therapy. We enrolled 72 patients with non‐small cell lung cancer (NSCLC) who received chemoradiotherapy (CRT) or chemotherapy (CT) prior to surgery. The ratio of the area of viable tumor cells to the total tumor area was calculated to obtain the %VTC. We also examined the number of CD4 (+), CD8 (+), CD20 (+) and FOXP3 (+) tumor‐infiltrating lymphocytes (TILs), podoplanin (PDPN) (+) cancer‐associated fibroblasts (CAFs), and CD204 (+) tumor‐associated macrophages (TAMs) by immunohistochemistry (IHC). In the CRT group (n= 37), the tumors had significantly lower %VTC than the CT group (n= 35) (P< 0.001). In both of the CT group and CRT group, the %VTC showed a significant positive correlation with the number of CD204 (+)‐TAMs (P= 0.014 and 0.005, respectively). Only in the CRT group, a higher number of CD204 (+) TAMs was associated with a shorter overall survival (OS) (P= 0.007) and recurrence‐free survival (RFS) (P= 0.015). In the CRT group, the number of CD204 (+) TAMs is associated with %VTC and prognosis, suggesting that these cells may have tumor‐promoting effects on the residual lung cancer in specific microenvironments after CRT.