Palladium-Catalyzed Oxidative Carbonylation of N-Allylamines for the Synthesis of β-Lactams
Palladium-Catalyzed Oxidative Carbonylation of N-Allylamines for the Synthesis of β-Lactams
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DOI：
10.1002/anie.201309081
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发表时间：
2014-02-24
影响因子：
16.6
通讯作者：
Lei, Aiwen
中科院分区：
文献类型：
--
作者：
Li, Wu;Liu, Chao;Lei, Aiwen
β-内酰胺支架被认为是合成含氮化合物的理想结构单元。报道了一种新的钯催化 N-烯丙胺氧化羰基化用于合成 α-亚甲基-β-内酰胺的方法。 DFT 计算表明，通过四元环过渡态形成 β-内酰胺是有利的。
beta-Lactam scaffolds are considered to be ideal building blocks for the synthesis of nitrogen-containing compounds. A new palladium-catalyzed oxidative carbonylation of N-allylamines for the synthesis of alpha-methylene-beta-lactams is reported. DFT calculations suggest that the formation of beta-lactams via a four-membered-ring transition state is favorable.