ROLE OF GENOTYPE AND DOPAMINE-RECEPTORS IN BEHAVIOR OF INBRED MICE IN A FORCED SWIMMING TEST
ROLE OF GENOTYPE AND DOPAMINE-RECEPTORS IN BEHAVIOR OF INBRED MICE IN A FORCED SWIMMING TEST
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DOI：
10.1007/bf02244374
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发表时间：
1991-01-01
影响因子：
3.4
通讯作者：
POPOVA, NK
中科院分区：
文献类型：
--
作者：
NIKULINA, EM;SKRINSKAYA, JA;POPOVA, NK
研究了选择性D1和D2多巴胺激动剂和拮抗剂对行为绝望（Porsolt试验）的影响中基因型的作用。 9个近交系小鼠的不动持续时间表现出显着的品系间差异。 多巴胺能药物的影响进行了评估，在6个菌株的特点是不同水平的游泳活动。 D1多巴胺受体激动剂SKF 38393（10 mg/kg）可增加游泳活动，而D1受体拮抗剂SCH 23390（0.2和0.5 mg/kg）可降低游泳活动，其作用具有基因型依赖性。 在强迫游泳试验中，D2多巴胺受体参与调节小鼠行为并不明显; D2激动剂溴隐亭（10 mg/kg）没有产生显著作用。 D2激动剂喹吡罗（2.5毫克/公斤）增加不动性在大多数小鼠品系的研究，而在CBA小鼠，它导致了显着减少不动性。 D2拮抗剂舒必利（20 mg/kg）减少不动性和增加主动游泳只有在两个菌株。 目前的结果表明，在调节小鼠游泳的D1和D2多巴胺受体的不同作用。
The role of genotype in the effects of selective D1 and D2 dopamine agonists and antagonists on behavioural despair (Porsolt's test) was studied. Mice of nine inbred strains showed significant interstrain differences in duration of immobility. The influence of dopaminergic drugs was assessed in six strains characterized by different levels of swimming activity. SKF 38393 (10 mg/kg), an agonist at D1 dopamine receptors, increased swimming activity, while the D1 antagonist SCH 23390 (0.2 and 0.5 mg/kg) reduced it, the effects being genotype dependent. The involvement of D2 dopamine receptors in the regulation of mouse behaviour in the forced swimming test was not so evident; the D2 agonist bromocriptine (10 mg/kg) produced no significant effect. The D2 agonist quinpirole (2.5 mg/kg) increased immobility in the majority of the mouse strains studied, while in CBA mice it resulted in a marked reduction of immobility. The D2 antagonist sulpiride (20 mg/kg) decreased immobility and increased active swimming only in two strains. The present results suggest a different role for D1 and D2 dopamine receptors in the regulation of swimming in the mouse.