Efficient preparation of three building blocks for the synthesis of heparan sulfate fragments:: Towards the combinatorial synthesis of oligosaccharides from hypervariable regions
Efficient preparation of three building blocks for the synthesis of heparan sulfate fragments:: Towards the combinatorial synthesis of oligosaccharides from hypervariable regions
复制标题
DOI：
10.1002/ejoc.200300254
复制
发表时间：
2003-09-15
影响因子：
2.8
通讯作者：
Bonnaffé, D
中科院分区：
文献类型：
--
作者：
Gavard, O;Hersant, Y;Bonnaffé, D
描述了获得适当保护的L-艾杜糖醛酸基单糖供体4和5以及2-叠氮基葡萄糖受体6和7的新的多克路线。然后从这些化合物通过有效的和区域选择性的保护基团操作制备L-艾杜糖醛酸基和D-葡萄糖醛酸基二糖1-3。这些二糖形成了合成硫酸乙酰肝素片段的组合方法的基础，硫酸乙酰肝素片段代表了该多糖的异质区域。(C)Wiley-VCH Verlag GmbH & Co. KGaA，69451魏因海姆，德国，2003.
New, multigram routes to suitably protected L-iduronyl monosaccharide donors 4 and 5 and 2-azidoglucose acceptors 6 and 7 are described. The L-iduronyl and D-glucuronyl disaccharides 1-3 were then prepared from these compounds, by means of efficient and regioselective protective group manipulations. These disaccharides form the basis of a combinatorial approach toward the synthesis of heparan sulfate fragments representative of the heterogeneous regions of this polysaccharide. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.